Table 4 The relationship between CD40 rs4810485 G > T and rs1883832 C > T polymorphisms and the disease severity of KOA
SNP | Severe | Moderate | Mild | χ2 | P |
|---|---|---|---|---|---|
(n = 40) | (n = 44) | (n = 49) | |||
rs4810485 G > T | |||||
GG | 26 (63.41) | 10 (23.26) | 8 (16.33) | ||
GT | 11 (27.5) | 24 (54.5) | 28 (57.1) | 25.38 | < 0.001 |
TT | 4 (10.00) | 9 (20.5) | 13 (26.53) | ||
G allele | 63 (78.75) | 44 (50.00) | 44 (44.90) | ||
T allele | 19 (23.75) | 42 (47.73) | 54 (55.10) | 20.17 | < 0.001 |
rs1883832 C > T | |||||
CC | 3 (7.32) | 7 (16.28) | 11 (22.4) | ||
CT | 20 (48.78) | 25 (58.14) | 30 (61.22) | 10.11 | 0.039 |
TT | 18 (43.90) | 11 (25.58) | 8 (16.33) | ||
C allele | 26 (32.50) | 39 (44.32) | 52 (53.06) | ||
T allele | 56 (70.00) | 47 (53.41) | 46 (46.94) | 8.358 | 0.015 |