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Table 3 Classification of functional capacity and measurement of joint changes in RA patients

From: Polymorphism and protein expression of MUTYH gene for risk of rheumatoid arthritis

  RA patients Chi-Square a
p value
Fisher’s Exact test a
p value
Genotype at rs3219463
G carrier - n (%) AA - n (%)
RA Diagnosis class
 I 88 (75.2) 13 (56.5) 0.315 0.199
 II 19 (16.2) 6 (26.1)
 III 8 (6.8) 3 (13.0)
 IV 2 (1.7) 1 (4.3)
  RA patients T-Test a
p value
Mann–Whitney U test a
p value
Genotype at rs3219463
G carrier - n (mean ± SD) AA - n (mean ± SD)
MUTYH serum level b 27 (20.98 ± 16.51) 13 (23.07 ± 17.16) 0.714 0.593
Joint pain 135 (31.93 ± 24.33) 28 (45.89 ± 25.46) 0.007 * 0.006 *
Joint stiffness 102 (0.62 ± 0.97) 19 (0.58 ± 0.72) 0.871 0.540
SJC 66 b 142 (1.96 ± 2.69) 26 (2.81 ± 3.18) 0.156 0.250
TJC 68 b 142 (3.83 ± 4.07) 26 (6.69 ± 7.06) 0.055 0.075
DAS 28 133 (3.88 ± 1.2) 25 (4.63 ± 1.23) 0.005 * 0.003 *
PtGA b 135 (39.65 ± 26.72) 27 (50.48 ± 27.82) 0.058 0.052
PrGA b 142 (23.73 ± 17.73) 27 (32.78 ± 23.38) 0.065 0.078
  1. a Nonparametric test
  2. b Mean value is lower in the G carrier / RA-non-risk-associated but data does not reach statistical significance
  3. * Statistically significant