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Table 1 Characteristics of the RA patients

From: Plasma miRNA expression profiles in rheumatoid arthritis associated interstitial lung disease

     

ILD(+)RA

UIP(+)RA

NSIP(+)RA

ILD(+)RA

UIP(+)RA

NSIP(+)RA

ILD(−)RA

P

P

P

Number

 

32

18

14

32

   

Age

year

70.2 (7.4)

70.6 (8.0)

69.6 (6.8)

57.7 (13.8)

0.0002

0.0013

0.0043

male number

n (%)

11 (34.4)

9 (50.0)

2 (14.3)

2 (6.3)

*0.0109

*0.0007

*0.5745

Disease duration

year

15.5 (12.6)

12.8 (12.2)

18.9 (12.7)

10.6 (7.4)

0.1830

0.8953

0.0116

Steinbrocker stage III and IV

n (%)

18 (56.3)

9 (50.0)

9 (64.3)

21 (65.6)

*0.6088

*0.3701

*1.0000

Smoker or past smoker

n (%)

10 (33.3)

7 (38.9)

3 (25.0)

10 (32.3)

*1.0000

*0.7581

*0.7272

Rheumatoid factor positive

n (%)

30 (93.8)

17 (94.4)

13 (92.9)

27 (84.4)

*0.4258

*0.3991

*0.6506

Anti-citrullinated peptide antibody positive

n (%)

31 (96.9)

18 (100.0)

13 (92.9)

31 (96.9)

*1.0000

*1.0000

*0.5208

KL-6

U/ml

1096.4 (853.7)

1086.2 (828.4)

1108.8 (914.9)

315.3 (257.9)

2.44 × 10−7

2.97 × 10−6

0.0001

SP-D

ng/ml

194.1 (244.7)

177.3 (192.3)

214.5 (303.0)

46.0 (37.5)

2.48 × 10−5

0.0008

0.0001

DAS28

 

4.0 (1.2)

3.7 (1.3)

4.3 (0.9)

3.1 (1.2)

0.0040

0.0793

0.0021

DAS28-CRP

 

3.0 (1.3)

2.6 (1.4)

3.4 (1.0)

2.4 (1.0)

0.0500

0.5855

0.0035

NSAIDs administration

n (%)

13 (41.9)

7 (38.9)

6 (46.2)

15 (48.4)

*0.7989

*0.5647

*1.0000

Corticosteroid administration

n (%)

26 (83.9)

14 (77.8)

12 (92.3)

25 (80.6)

*1.0000

*1.0000

*0.6542

DMARDs administration

n (%)

24 (77.4)

14 (77.8)

10 (76.9)

30 (96.8)

*0.0529

*0.0542

*0.0706

sDMARDs administration

n (%)

19 (61.3)

11 (61.1)

8 (61.5)

19 (61.3)

*1.0000

*1.0000

*1.0000

bDMARDs administration

n (%)

10 (32.3)

5 (27.8)

5 (38.5)

22 (71.0)

*0.0048

*0.0066

*0.0874

  1. Average values or numbers of each group are shown. Standard deviations or percentages are shown in parenthesis. Differences were tested by Mann-Whitney’s U test or Fisher’s exact test using 2 × 2 contingency tables
  2. RA rheumatoid arthritis, ILD interstitial lung disease, UIP Usual interstitial pneumonia, NSIP Nonspecific interstitial pneumonia, ILD(+)RA RA with ILD, UIP(+)RA RA with ILD of UIP pattern, NSIP(+)RA RA with ILD of NSIP pattern, ILD(−)RA RA without ILD, KL-6 krebs von den lungen-6, SP-D Surfactant protein-D, DAS28 disease activity score 28, NSAIDs non-steroidal anti- inflammatory drug, DMARD disease-modifying anti-rheumatic drug, sDMARD synthetic DMARD, bDMARD biological DMARD
  3. *Fisher’s exact test was employed