Fig. 1

Evaluation of the miRNA expression levels, as a marker for interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients. a Distribution of the hsa-miR-214-5p. The filled square, filled circle, and empty circle represent RA without ILD, RA with usual interstitial pneumonia, and RA with nonspecific interstitial pneumonia, respectively. Horizontal bars denote means. The horizontal dotted line represents an optimized cut-off level (hsa-miR-214-5p = 0.429, with specificity and sensitivity of 0.906 and 0.375, respectively). ILD(+)RA: RA with ILD, ILD(−)RA: RA without ILD. b Distribution of the hsa-miR-7-5p. The horizontal dotted line represents an optimized cut-off level (hsa-miR-7-5p = 5.686, with specificity and sensitivity of 0.875 and 0.469, respectively). c The receiver operating characteristic (ROC) curve using the hsa-miR-214-5p (dotted line) and hsa-miR-7-5p (solid line) as markers for ILD in RA. The area under the curve (AUC) value of the ROC curve for hsa-miR-214-5p is 0.634 and that for hsa-miR-7-5p is 0.652. d Distribution of miRNA index (214, 7) generated from hsa-miR-214-5p and hsa-miR-7-5p for ILD (=0.0095 X hsa-miR-214-5p + 0.0008 X hsa-miR-7-5p). The horizontal dotted line represents an optimized cut-off level (miRNA index (214, 7) = 0.004, with specificity and sensitivity of 0.813 and 0.656, respectively). e The ROC curve using miRNA index (214, 7) as a marker for ILD in RA. The AUC value of the ROC curve is 0.740