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Table 3 Unadjusted and adjusted association of osteonecrosis with death, surgical site infection (SSI), venous thromboembolism (VTE), and revision compared to osteoarthritis in patients undergoing total hip arthroplasty

From: An underlying diagnosis of osteonecrosis of bone is associated with worse outcomes than osteoarthritis after total hip arthroplasty

Osteonecrosis vs. Osteoarthritis Unadjusted OR (95%CI) p-value Adjusted OR (95%CI) p-value
 Death, 90 daysa 2.12 (1.23–3.66) 0.007 2.48 (1.31–4.72) 0.006
 SSI (deep and superficial)b 1.45 (0.97–2.18) 0.069 1.67 (1.11–2.51) 0.013
 VTE (DVT and PE), <90 daysc 1.16 (0.78–1.70) 0.466 1.37 (0.92–2.03) 0.118
 Readmission, 90 days unplannedd 1.89 (1.43–2.48) <0.001 2.20 (1.67–2.91) <0.001
  Unadjusted HR (95%CI) p-value Adjusted HR (95%CI) p-value
 Revision (within 1 Year)e 1.00 (0.70–1.44) 0.992 0.92 (0.63–1.33) 0.652
 Revision (after 1 Year) 1.44 (1.04–2.01) 0.030 1.32 (0.94–1.84) 0.109
  1. SSI surgical site infection, as defined by the CDC, VTE venous thromboembolism, DVT deep vein thrombosis, PE pulmonary embolism- as defined by AHRQ, OR odds ratio, HR hazard ratio, CI confidence interval
  2. All multivariable models were adjusted for covariates if they changed estimates by >10% and p < 0.10 in univariate analyses or deemed clinically important for the relationship studied
  3. aAdjusted model excluded cases with missing BMI (641, 1.4%) and ASA (1,487, 3.1%), final n = 45,431 (95.6%). Multivariable-adjusted model was adjusted for age, race, BMI, and ASA
  4. bThe combined SSI includes 30-day superficial SSI and 1-year deep SSI. Adjusted model excluded cases with missing BMI (641, 1.4%), ad patients who died or left the system within 1 year (1,539, 3.2%), final n = 45506 (95.8%). Multivariable-adjusted model was adjusted for BMI
  5. cThe combined VTE outcome includes deep vein thrombosis and pulmonary embolism. Adjusted model excluded cases where patients either died or left the system within 90 days (n = 370, 0.8%), final n = 47,153 (99.2%). Multivariable-adjusted model was adjusted for age
  6. dReadmissions includes limited sample (operative years 2009–2012 and 3 geographical regions), n = 17,179. Final adjusted model excluded cases where patients either died or left the system within 90 days (n = 85, 0.5%), final n = 17,094 (99.5%). Multivariable-adjusted model was adjusted for age
  7. eAdjusted model had no exclusions due to missing values, n = 47,523 (100%). Multivariable-adjusted model was adjusted for age