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Table 3 Non-parametric correlation of change in serum cytokine and neurotransmitter levels from baseline to 2-months with change in WOMAC pain at 2-month post-injection in painful TKA, showing statistically significant associations

From: Cytokine and neuropeptide levels are associated with pain relief in patients with chronically painful total knee arthroplasty: a pilot study

Baseline to 2-month change in serum levels* Spearman’s correlation coefficient P-value
IL2 −0.37 0.03
IL7 −0.42 0.01
IL8 −0.51 0.002
IL9 −0.50 0.002
IL16 −0.48 0.004
IL12p70 −0.56 <0.001
GCSF −0.34 0.04
IFN gamma −0.48 0.003
IP10 −0.38 0.02
MCP −0.35 0.03
MIP1b −0.49 0.003
TNF-alpha −0.42 0.01
VEGF −0.38 0.02
  1. *Data from 35 patients were available
  2. Only those cytokines that had a significant p-value <0.05 are listed in bold; other cytokines were not significantly associated with change in WOMAC pain at 2-month post-TKA