Cytokine and neuropeptide levels are associated with pain relief in patients with chronically painful total knee arthroplasty: a pilot study

Table 3 Non-parametric correlation of change in serum cytokine and neurotransmitter levels from baseline to 2-months with change in WOMAC pain at 2-month post-injection in painful TKA, showing statistically significant associations

Baseline to 2-month change in serum levels*	Spearman’s correlation coefficient	P-value
IL2	−0.37	0.03
IL7	−0.42	0.01
IL8	−0.51	0.002
IL9	−0.50	0.002
IL16	−0.48	0.004
IL12p70	−0.56	<0.001
GCSF	−0.34	0.04
IFN gamma	−0.48	0.003
IP10	−0.38	0.02
MCP	−0.35	0.03
MIP1b	−0.49	0.003
TNF-alpha	−0.42	0.01
VEGF	−0.38	0.02

*Data from 35 patients were available
Only those cytokines that had a significant p-value <0.05 are listed in bold; other cytokines were not significantly associated with change in WOMAC pain at 2-month post-TKA