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Table 2 Mean differences of QALYs and HOOS or KOOS for the 61-week follow-up period

From: Supervised neuromuscular exercise prior to hip and knee replacement: 12-month clinical effect and cost-utility analysis alongside a randomised controlled trial

 

Intervention (n = 84)

Control (n = 81)

  

n

Mean (SE)

n

Mean (SE)

Mean difference (95% CI)

ES

QALY, LTAPa

84

0.66 (0.04)

81

0.61 (0.04)

0.04 (0.01 to 0.07)

 

QALY, LTAPb

84

0.80 (0.01)

81

0.74 (0.01)

0.06 (0.02 to 0.09)

 

QALY, LOCFa

82

0.64 (0.05)

79

0.58 (0.05)

0.05 (0.02 to 0.09)

 

QALY, completea

63

0.68 (0.05)

59

0.63 (0.05)

0.05 (0.02 to 0.09)

 

QALY, per-protocola

62

0.63 (0.04)

81

0.59 (0.05)

0.04 (0.01 to 0.07)

 

HOOS/KOOS

 ADL

84

35.9 (2.1)

81

32.1 (2.4)

3.80 (−2.45 to 10.07)

0.24

 Pain

84

41.2 (2.2)

81

37.1 (2.4)

4.13 (−2.33 to 10.60)

0.29

 Symptoms

84

33.9 (2.7)

81

32.2 (2.6)

1.69 (−5.79 to 9.17)

0.09

 Sport and Recreation

84

33.1 (3.6)

81

26.3 (2.8)

6.79 (−2.10 to 15.69)

0.39

 Quality of Life

84

43.4 (2.6)

81

35.2 (3.0)

8.25 (0.42 to 16.10)

0.59

  1. Mean (bootstrap SE) and mean differences (95% confidence interval). ES, effect-size (mean difference/pooled standard deviation)
  2. QALY, quality-adjusted life-years; complete, complete item response analysis; LTAP, linear trend at point; LCOF, last observation carried forward; per-protocol, per-protocol analysis equals attending ≥12 exercise sessions. HOOS, Hip disability and Osteoarthritis Outcome Score; KOOS, Knee injury and Osteoarthritis Outcome Score; ADL, function in daily living
  3. aAdjusted for baseline EQ-5D-3 L scores
  4. bUnadjusted analysis