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Table 2 Mean differences of QALYs and HOOS or KOOS for the 61-week follow-up period

From: Supervised neuromuscular exercise prior to hip and knee replacement: 12-month clinical effect and cost-utility analysis alongside a randomised controlled trial

  Intervention (n = 84) Control (n = 81)   
n Mean (SE) n Mean (SE) Mean difference (95% CI) ES
QALY, LTAPa 84 0.66 (0.04) 81 0.61 (0.04) 0.04 (0.01 to 0.07)  
QALY, LTAPb 84 0.80 (0.01) 81 0.74 (0.01) 0.06 (0.02 to 0.09)  
QALY, LOCFa 82 0.64 (0.05) 79 0.58 (0.05) 0.05 (0.02 to 0.09)  
QALY, completea 63 0.68 (0.05) 59 0.63 (0.05) 0.05 (0.02 to 0.09)  
QALY, per-protocola 62 0.63 (0.04) 81 0.59 (0.05) 0.04 (0.01 to 0.07)  
HOOS/KOOS
 ADL 84 35.9 (2.1) 81 32.1 (2.4) 3.80 (−2.45 to 10.07) 0.24
 Pain 84 41.2 (2.2) 81 37.1 (2.4) 4.13 (−2.33 to 10.60) 0.29
 Symptoms 84 33.9 (2.7) 81 32.2 (2.6) 1.69 (−5.79 to 9.17) 0.09
 Sport and Recreation 84 33.1 (3.6) 81 26.3 (2.8) 6.79 (−2.10 to 15.69) 0.39
 Quality of Life 84 43.4 (2.6) 81 35.2 (3.0) 8.25 (0.42 to 16.10) 0.59
  1. Mean (bootstrap SE) and mean differences (95% confidence interval). ES, effect-size (mean difference/pooled standard deviation)
  2. QALY, quality-adjusted life-years; complete, complete item response analysis; LTAP, linear trend at point; LCOF, last observation carried forward; per-protocol, per-protocol analysis equals attending ≥12 exercise sessions. HOOS, Hip disability and Osteoarthritis Outcome Score; KOOS, Knee injury and Osteoarthritis Outcome Score; ADL, function in daily living
  3. aAdjusted for baseline EQ-5D-3 L scores
  4. bUnadjusted analysis