Table 3 Characteristics of the included studies
From: Genes associated with persistent lumbar radicular pain; a systematic review
Study | Cases | Pain local. | Pain time points | Gene | Biomarker | Results |
|---|---|---|---|---|---|---|
Andrade et al. (2013) [39] | n = 10 | Leg | 1 day preoperative 6 weeks postoperative 12 month postoperative | (Tissue: PM, AF, NP) IL-1beta, IL-6 | – – | |
Andrade et al. (2011) [38] | n = 10 | Leg | 1 day preoperative 6 week postopertive 12 mont postoperative | (Tissue: PM, AF, NP) TNF alfa TNF R1 TNF R2 | ↑ (6 week r = 0.54, 12 month r = 0.65) ↑ (6 week r = 0.75, 12 month r = 0.80) ↓ (6 week r = -0.60, 12 month r = -0.60) | |
Gebhardt et al. (2006) [37] | n = 31 | ND | 0 day, 3 day, 7 day, 10 day, 14 day, 17 day, 21 day, 2,3 month, 6 month | (Blood) hsCRP | ↓ (first 3 weeks p < 0.05) - (after 3 weeks) | |
Hasvik et al. (2014) [21] | n = 118 | Leg | Baseline 12 month | OPRM1 | ↑ (Women p < 0.008) ↓ (Men p < 0.008) | |
Jacobsen et al. (2013) [44] | n = 260 | Leg Back | Baseline 6 week 12 month | MMP1 | ↑ (6 week p = 0.004, 12 month p = 0.004) | |
Jacobsen et al. (2012) [43] | n = 258 | ND Activity | Baseline 6 month postoperative 12 month postoperative | COMT | ↑ (6 month p = 0.028) | |
Karppinen et al. (2008) [29] | n = 153 | Leg Back | Baseline 6 week 6 month 12 month | IL-6 | – | |
Moen et al. (2014) [31] | n = 252 | Activity | Baseline 6 week 6 month 12 month | 1 L-1a + IL-1RN IL-1b + IL-1RN | ↑ (12 month p = 0.049) – | |
Olsen et al. (2012) [20] | n = 258 | Leg Back Activity | Baseline 6 week 6 month 12 month | OPRM1 | ↑ (12 month Women p = 0.002) ↓ (12 month Men p = 0.002) | |
Rut et al. (2014) [40] | n = 176 | Leg Back | Preoperative 12 month postoperative | COMT | ↑ (12 month p = 0.0042) | |
Schistad et al. (2014) [42] | n = 108 | Leg Back Activity Rest | Baseline 12 month | (Blood) IL-6 | ↑ (12 month p = 0.004) | |
Schistad et al. (2014) [30] | n = 121 | Leg Back Activity Rest Present | Baseline 6 week 12 month | IL-1a | ↑ (12 month p = 0.002) | |
Scuderi et al. (2009) [45] | n = 47 | ND | Preinjection 3 month postinjection | (CSF) IFNa IL2,4,5,6,7,8,10,12,13,17 G-CSF GM-CSF TNFa IL1b MCP-1b MIP-1b | ↓ (3 month p = 0.001) – – – – – – – | |
Takeuchi et al. (2007) [41] | n = 27 | Leg | Preoperative 3 week postoperative | (Blood) CGRP1 Galanin Neuro-peptide4 SubstP | ↑ (Preoperative p = 0.01) – – – | |
Tegeder et al. (2006) [24] | n = 168 | ND | 4 time pointsa | GCH | ↓ (p < 0,05) |