Genes associated with persistent lumbar radicular pain; a systematic review

Table 2 Genetic variability and pain recovery

Gene	rs number	Base substitution	Position in DNA	Amino acid substitution	Reference	Result
OPRM1	rs1799971	A→G	118	Asn40Asp	Hasvik et al. (2014) [21]	↑(W) ↓(M)
OPRM1	rs1799971	A→ G	118	Asn40Asp	Olsen et al. (2012) [20]	↑(W) ↓(M)
COMT	rs4680	A→ G	472	Val158Met	Jacobsen (2012) [43]	↑
	rs4680	A→ G	158	Val 158Met	Rut et al. (2014) [40]	↓
	rs6269	G→ A	−98	–		–
	rs4633	T→ C	186	–		↓
	rs4818	G→ C	408	–		–
MMP1	rs 1799750	1G allele→ 2G allele	−1719	–	Jacobsen (2013) [44]	↑
IL1A	rs1800587	C→ T	−949	–	Moen et al. (2014) [31]	↑
IL1A	rs1800587	C→ T	−949	–	Schistad et al. (2014) [30]	↑
IL1B	rs1143627	T→ C	−118	–	Moen et al. (2014) [31]	–
IL1RN	rs2234677	G→ A	−87	–	Moen et al. (2014) [31]	↑
IL-6	rs1800797 rs1800796	A→ G	−661	–	Karppinen et al. (2008) [29]	- (Haplotype GGGA)
	rs1800797 rs1800796	G→ C	−636	–
	rs1800795	G→ C	−237	–
	rs13306435	T→ A	486	Asp162Glu
GCH1	rs8007267	G→ A	−9610	–	Tegeder et al. (2006) [24]	↓ (Haplotype ATCA)
	rs3783641	A→ T	343 + 8900	–
	rs8007201	T→ C		–
	rs752688	G→ A	509 + 1551 627–708	–

The rs number refers to a specific SNP and rs stands for Reference SNP cluster ID, created by National Center for Biotechnology Information (NCBI) (Ref.: http://www.ncbi.nlm.nih.gov/). Base substitution refers to replacement of one base with another in DNA. Position on DNA based on information from NCBI. Only two of our SNP causes a direct amino acid substitution. A change of nucleotide in the exon is a prerequisite for change in amino acid. A replacement of nucleotide in the intron does not cause such a substitution but may have a role in the transcription process. Polymorphism located in the promotor part of the gene is expressed by adding minus prior to the position on the DNA
↑ (positive association with poor recovery), ↓ (negative association with poor recovery), - (no change in amino acid), - (no association with poor recovery), W (Women), M (Men)

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