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Table 2 Genetic variability and pain recovery

From: Genes associated with persistent lumbar radicular pain; a systematic review

Gene rs number Base substitution Position in DNA Amino acid substitution Reference Result
OPRM1 rs1799971 A→G 118 Asn40Asp Hasvik et al. (2014) [21] ↑(W) ↓(M)
rs1799971 A→ G 118 Asn40Asp Olsen et al. (2012) [20] ↑(W) ↓(M)
COMT rs4680 A→ G 472 Val158Met Jacobsen (2012) [43]
  rs4680 A→ G 158 Val 158Met Rut et al. (2014) [40]
rs6269 G→ A −98
rs4633 T→ C 186
rs4818 G→ C 408
MMP1 rs 1799750 1G allele→ 2G allele −1719 Jacobsen (2013) [44]
IL1A rs1800587 C→ T −949 Moen et al. (2014) [31]
rs1800587 C→ T −949 Schistad et al. (2014) [30]
IL1B rs1143627 T→ C −118 Moen et al. (2014) [31]
IL1RN rs2234677 G→ A −87
IL-6 rs1800797 rs1800796 A→ G −661 Karppinen et al. (2008) [29] - (Haplotype GGGA)
G→ C −636
rs1800795 G→ C −237
rs13306435 T→ A 486 Asp162Glu
GCH1 rs8007267 G→ A −9610 Tegeder et al. (2006) [24] ↓ (Haplotype ATCA)
rs3783641 A→ T 343 + 8900
rs8007201 T→ C  
rs752688 G→ A 509 + 1551 627–708
  1. The rs number refers to a specific SNP and rs stands for Reference SNP cluster ID, created by National Center for Biotechnology Information (NCBI) (Ref.: Base substitution refers to replacement of one base with another in DNA. Position on DNA based on information from NCBI. Only two of our SNP causes a direct amino acid substitution. A change of nucleotide in the exon is a prerequisite for change in amino acid. A replacement of nucleotide in the intron does not cause such a substitution but may have a role in the transcription process. Polymorphism located in the promotor part of the gene is expressed by adding minus prior to the position on the DNA
  2. ↑ (positive association with poor recovery), ↓ (negative association with poor recovery), - (no change in amino acid), - (no association with poor recovery), W (Women), M (Men)