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Table 5 Associations with bDMARDs (1) or no bDMARDs (0), univariate and multiple logistic regression analyses

From: Comparisons between comorbid conditions and health care consumption in rheumatoid arthritis patients with or without biological disease-modifying anti-rheumatic drugs: a register-based study

Covariates

Univariate analyses (sex- and age-adjusted)

Multiple analysis

Odds ratio

95% confidence intervals

P-value

Odds ratio

95% confidence intervals

P-value

Age (per 1 year)

0.97

0.97–0.97

<0.001

0.98

0.97–0.98

<0.001

Sex

0.88

0.76–1.03

0.103

0.94

0.81–1.10

0.450

Comorbid conditions

 

 Diabetes

0.86

0.69–1.09

0.218

0.96

0.76–1.22

0.758

 Hypertension

0.89

0.76–1.03

0.108

0.95

0.81–1.11

0.513

 Ischemic heart disease

0.73

0.58–0.93

0.009

0.90

0.70–1.15

0.384

 Atrial fibrillation or flutter

0.64

0.47–0.86

0.004

0.83

0.60–1.15

0.260

 Heart failure

0.40

0.28–0.58

<0.001

0.47

0.32–0.69

<0.001

 Valvular disease

0.82

0.53–1.27

0.375

1.11

0.70–1.75

0.657

 Cerebrovascular disease

0.59

0.43–0.82

0.001

0.65

0.47–0.90

0.010

 Venous thromboembolic disease

0.83

0.61–1.14

0.259

0.92

0.67–1.27

0.607

 Chronic respiratory disease

0.80

0.66–0.98

0.031

0.82

0.67–0.998

0.048

 Chronic renal insufficiency

0.43

0.21–0.89

0.022

0.53

0.25–1.09

0.084

 Depression

0.72

0.58–0.90

0.004

0.74

0.59–0.92

0.008

 Malignancy

0.66

0.52–0.84

0.001

0.66

0.52–0.84

0.001

 Infections

1.39

1.21–1.61

<0.001

1.52

1.31–1.76

<0.001

 Fractures

1.01

0.77–1.33

0.947

1.06

0.81–1.41

0.660

Health care consumption

 

 Patients hospitalizeda

1.15

1.01–1.31

0.040

   

 Number of inpatient admissionsa

1.03

1.00–1.07

0.042

   

 Cumulative days at hospitala

0.997

0.99–1.00

0.101

   

 Outpatient visits, secondary care

1.06

1.06–1.07

<0.001

   

 Outpatient visits, primary care

0.97

0.96–0.98

<0.001

   
  1. Analyses were performed with (multiple) logistic regression models and expressed as Odds ratios (with 95% confidence intervals and p-value). In the univariate analyses, each covariate was adjusted for sex and age. Age and sex were adjusted for each other. In the multivariable analysis, all of the comorbid conditions covariates in the table were included in the model
  2. aHospitalizations of one day and connected to an intravenous treatment were not included