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Table 1 Demographics, disease-related characteristics and outcomes of non-fracture and fracture groups in 268 patients with osteosarcoma

From: Pathological fractures in predicting clinical outcomes for patients with osteosarcoma

Characteristics

Non- Fracture

N = 234 (87.3%)

Fracture

N = 34 (12.7%)

p*

N

%, or mean ± SD

N

%, or mean ± SD

Gender

 Males

141

60.3

19

55.9

0.030

 Females

93

39.7

15

44.1

Age, years

 Mean

 

22.8 ± 15.2

 

23.5 ± 19.1

0.836

  ≤ 10

24

10.3

5

14.7

0.626

 10–20

124

53.0

19

55.9

  > 20

84

35.9

10

29.4

Stage of tumor a

 IB

4

3.2

0

0

0.112

 IIB

202

86.3

27

79.4

 III

28

22.6

7

38.9

Tumor size, mm2

148

363.7 ± 641.1

16

389.4 ± 845.9

0.907

Tumor location

 Femur

94

40.2

18

52.9

0.020

 Tibia

49

20.9

3

8.8

 Humerus

16

6.8

10

29.4

 Fibula

6

2.6

1

2.9

 Others b

21

9.0

2

5.9

 Not Specified

48

20.5

0

0.0

Lung metastasis c

 No

159

67.9

17

50.0

0.039

 Yes

75

32.1

17

50.0

Necrosis rate, %

  < 90% (poor)

41

31.1

13

44.8

0.351

  ≥ 90% (good)

65

49.2

12

41.4

 No preoperative C/T d

26

19.7

4

13.8

Local recurrence

 No

183

78.2

26

76.5

0.820

 Yes

51

21.8

8

23.5

Status until last follow up

 No evidence of disease

108

46.4

16

47.1

0.904

 Alive with disease

35

15.1

6

17.6

 Died of disease

89

38.4

12

35.3

Duration to recurrence, months

41

23.1 ± 20.9

5

12.8 ± 9.4

0.084

Follow up duration, months

234

68.0 ± 52.1

34

65.2 ± 57.7

0.362

Overall survival, months

234

65.7 ± 48.9

34

56.4 ± 52.3

0.338

Progression free survival, months

134

67.9 ± 52.0

20

65.2 ± 57.7

0.841

Disease-free survival, months

108

87.1 ± 48.1

16

80.8 ± 55.1

0.667

  1. aEnneking stage
  2. bOthers included radius, pelvis, hip, sinonasal, skull, spine, neck, and scapula
  3. c Metastasis at diagnosis or developed during follow-up
  4. dC/T: chemotherapy
  5. *Comparisons were based on the independent student t-test and Pearson chi square test