From: Pathological fractures in predicting clinical outcomes for patients with osteosarcoma
Characteristics | Non- Fracture N = 234 (87.3%) | Fracture N = 34 (12.7%) | p* | ||
---|---|---|---|---|---|
N | %, or mean ± SD | N | %, or mean ± SD | ||
Gender | |||||
 Males | 141 | 60.3 | 19 | 55.9 | 0.030 |
 Females | 93 | 39.7 | 15 | 44.1 | |
Age, years | |||||
 Mean |  | 22.8 ± 15.2 |  | 23.5 ± 19.1 | 0.836 |
  ≤ 10 | 24 | 10.3 | 5 | 14.7 | 0.626 |
 10–20 | 124 | 53.0 | 19 | 55.9 | |
  > 20 | 84 | 35.9 | 10 | 29.4 | |
Stage of tumor a | |||||
 IB | 4 | 3.2 | 0 | 0 | 0.112 |
 IIB | 202 | 86.3 | 27 | 79.4 | |
 III | 28 | 22.6 | 7 | 38.9 | |
Tumor size, mm2 | 148 | 363.7 ± 641.1 | 16 | 389.4 ± 845.9 | 0.907 |
Tumor location | |||||
 Femur | 94 | 40.2 | 18 | 52.9 | 0.020 |
 Tibia | 49 | 20.9 | 3 | 8.8 | |
 Humerus | 16 | 6.8 | 10 | 29.4 | |
 Fibula | 6 | 2.6 | 1 | 2.9 | |
 Others b | 21 | 9.0 | 2 | 5.9 | |
 Not Specified | 48 | 20.5 | 0 | 0.0 | |
Lung metastasis c | |||||
 No | 159 | 67.9 | 17 | 50.0 | 0.039 |
 Yes | 75 | 32.1 | 17 | 50.0 | |
Necrosis rate, % | |||||
  < 90% (poor) | 41 | 31.1 | 13 | 44.8 | 0.351 |
  ≥ 90% (good) | 65 | 49.2 | 12 | 41.4 | |
 No preoperative C/T d | 26 | 19.7 | 4 | 13.8 | |
Local recurrence | |||||
 No | 183 | 78.2 | 26 | 76.5 | 0.820 |
 Yes | 51 | 21.8 | 8 | 23.5 | |
Status until last follow up | |||||
 No evidence of disease | 108 | 46.4 | 16 | 47.1 | 0.904 |
 Alive with disease | 35 | 15.1 | 6 | 17.6 | |
 Died of disease | 89 | 38.4 | 12 | 35.3 | |
Duration to recurrence, months | 41 | 23.1 ± 20.9 | 5 | 12.8 ± 9.4 | 0.084 |
Follow up duration, months | 234 | 68.0 ± 52.1 | 34 | 65.2 ± 57.7 | 0.362 |
Overall survival, months | 234 | 65.7 ± 48.9 | 34 | 56.4 ± 52.3 | 0.338 |
Progression free survival, months | 134 | 67.9 ± 52.0 | 20 | 65.2 ± 57.7 | 0.841 |
Disease-free survival, months | 108 | 87.1 ± 48.1 | 16 | 80.8 ± 55.1 | 0.667 |