Fig. 2

a-f Cytokine production in response to metals. Cytokine production in response to metals (0.1 mM and 0.01 mM) in the two patient groups compared to controls. Group 1 = patients scheduled for pTKA, labelling for a clinical history of metal allergy; Group 2A = TKA patients with pain and clinical signs of metal allergies; Group 2B = TKA patients with pain and no clinical signs of metal allergies; Group 3 = Control subjects. Metals: (a) = Chromium chloride; (b) = Chromium; (c) = Nickel chloride; (d) = Nickel; (e) = Cobalt; (f) = Molybdenum. (SI = mean of Stimulation Index). Asterisks indicate: (*) p < 0.05; (**) p < 0.005