Assessment of subchondral bone marrow lesions in knee osteoarthritis by MRI: a comparison of fluid sensitive and contrast enhanced sequences

Table 6 Median differences in change of WOMAC scores and imaging parameters from baseline to follow-up

Method	Segmentation parameter	Baseline, median (range)	Follow-up, median (range)	p-values*
WOMAC_total	N.A.	794 (76–1444)	234 (9–1782	0.023
WOMAC_pain	N.A.	140 (18–311)	44 (3–373)	0.054
MS	CEA-BML	6.5 (0–67.0)	7.5 (0–79.4)	0.21
MS	BML	8.1 (0–70.5)	11.4 (0–86.8)	0.71
CAS	CEA-BML^a	8.1 (0.1–44.9)	8.6 (1.0–81.3)	0.18
CAS	BML	5.6 (0.1–39.8)	5.3 (0.6–79.8)	0.97
Dynamika	N_voxel	29.3 (0.0–99.3)	18.8 (0.0–86.1)	0.13
	MExN_voxel	379.4 (0.0–1442.1)	281.6 (0.0–1679.5)	0.13
	IRExN_voxel	0.2 (0.0–3.3)	0.2 (0.0–4.1)	0.45

Data was analyzed using imaging data from the entire medial knee joint. CEA-BML, BML and N_voxel were calculated based on the relative involvement. MExN_voxel and IRExN_voxel were calculated by multiplying the absolute number of N_voxel by ME and IRE, respectively
N.A. not applicable
*Changes from baseline to follow-up, Wilcoxon’s signed rank test
^a5 femoral and 3 tibial outliers excluded

ISSN: 1471-2474