Fig. 2From: Association of a rare NOTCH4 coding variant with systemic sclerosis: a family-based whole exome sequencing studyA family with systemic sclerosis segregating a mutation in NOTCH4. a Pedigree of the family under study. There are three affecteds (filled symbols). Proband is indicated by an arrow. b Sanger sequencing validation of the NOTCH4 p.Met1415Ile variant. Arrowheads show the heterozygous C > T mutation in the chromatogramsBack to article page