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Table 9 Twenty-four month change in semi-quantitative MRI biomarkers – meniscus

From: Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort − Methodologic aspects and definition of change

MRI feature

Biomarker

Overall n (%)

Controls

Cases

p-value

 

 Yes

102 (17 %)

59 (14.5 %)

43 (22.2 %)

 

Meniscus

Meniscal Morphology: 24 Month Number of regions with worsening

    

 0

505 (84 %)

365 (90.1 %)

140 (72.2 %)

 

 1

67 (11 %)

31 (7.7 %)

36 (18.6 %)

 

 2

25 (4 %)

7 (1.7 %)

18 (9.3 %)

 

 3

1 (0 %)

1 (0.2 %)

0 (0.0 %)

 

 5

1 (0 %)

1 (0.2 %)

0 (0.0 %)

 
 

Meniscal Morphology: 24 Month Any regions with worsening

   

<0.001

 No

505 (84 %)

365 (90.1 %)

140 (72.2 %)

 

 Yes

94 (16 %)

40 (9.9 %)

54 (27.8 %)

 
 

Meniscal Extrusion Medial - 24 Month worsening

   

<0.001

 No

512 (86 %)

369 (91.3 %)

143 (74.1 %)

 

 Yes

85 (14 %)

35 (8.7 %)

50 (25.9 %)

 
 

Meniscal Extrusion Lateral - 24 Month worsening

    

 No

599 (100 %)

405 (99.8 %)

194 (100.0 %)

 

 Yes

1 (0 %)

1 (0.2 %)

0 (0.0 %)

 
  1. *statistically significant at p < 0.05; p values refer to differences between cases and controls across all grades