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Table 5 Baseline frequencies of semi-quantitative MRI biomarkers – cartilage

From: Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort − Methodologic aspects and definition of change

MRI feature

Biomarker

Overall n (%)

Controls

Cases

p-value

Cartilage

MOAKS Cartilage Morphology-Thickness-Max score across entire knee

   

0.012*

 0

150 (25 %)

118 (29.1 %)

32 (16.5 %)

 

 1

127 (21 %)

83 (20.4 %)

44 (22.7 %)

 

 2

290 (48 %)

184 (45.3 %)

106 (54.6 %)

 

 3

33 (6 %)

21 (5.2 %)

12 (6.2 %)

 

MOAKS Cartilage Morphology-Thickness-Number of subregions with score > 0 across entire knee

    

 0

150 (25 %)

118 (29.1 %)

32 (16.5 %)

 

 1

169 (28 %)

112 (27.6 %)

57 (29.4 %)

 

 2

123 (21 %)

82 (20.2 %)

41 (21.1 %)

 

 3

78 (13 %)

46 (11.3 %)

32 (16.5 %)

 

 4

54 (9 %)

34 (8.4 %)

20 (10.3 %)

 

 5

19 (3 %)

11 (2.7 %)

8 (4.1 %)

 

 6

4 (1 %)

2 (0.5 %)

2 (1.0 %)

 

 7

3 (1 %)

1 (0.2 %)

2 (1.0 %)

 

MOAKS Cartilage Morphology-Thickness-Number of subregions with score > 0 across entire knee category

   

0.002*

 0

150 (25 %)

118 (29.1 %)

32 (16.5 %)

 

 1,2

292 (49 %)

194 (47.8 %)

98 (50.5 %)

 

 3+

158 (26 %)

94 (23.2 %)

64 (33.0 %)

 

MOAKS Cartilage Morphology-Surface Area - Max score across entire knee

    

 0

12 (2 %)

12 (3.0 %)

0 (0.0 %)

 

 1

28 (5 %)

22 (5.4 %)

6 (3.1 %)

 

 2

430 (72 %)

297 (73.2 %)

133 (68.6 %)

 

 3

130 (22 %)

75 (18.5 %)

55 (28.4 %)

 

MOAKS Cartilage Morphology-Surface Area - Max score across entire knee Category

   

0.004*

 0–1

40 (7 %)

34 (8.4 %)

6 (3.1 %)

 

 2

430 (72 %)

297 (73.2 %)

133 (68.6 %)

 

 3

130 (22 %)

75 (18.5 %)

55 (28.4 %)

 

MOAKS Cartilage Morphology-Surface Area-Number of subregions with score > 0 across entire knee

    

 0

12 (2 %)

12 (3.0 %)

0 (0.0 %)

 

 1

33 (6 %)

28 (6.9 %)

5 (2.6 %)

 

 2

50 (8 %)

34 (8.4 %)

16 (8.2 %)

 

 3

78 (13 %)

59 (14.5 %)

19 (9.8 %)

 

 4

102 (17 %)

81 (20.0 %)

21 (10.8 %)

 

 5

111 (19 %)

69 (17.0 %)

42 (21.6 %)

 

 6

88 (15 %)

54 (13.3 %)

34 (17.5 %)

 

 7

50 (8 %)

30 (7.4 %)

20 (10.3 %)

 

 8

36 (6 %)

18 (4.4 %)

18 (9.3 %)

 

 9

23 (4 %)

12 (3.0 %)

11 (5.7 %)

 

 10

13 (2 %)

7 (1.7 %)

6 (3.1 %)

 

 11

2 (0 %)

1 (0.2 %)

1 (0.5 %)

 

 12

1 (0 %)

1 (0.2 %)

0 (0.0 %)

 

 13

1 (0 %)

0 (0.0 %)

1 (0.5 %)

 

MOAKS Cartilage Morphology-Surface Area - Number of subregions with score > 0 across entire knee category

   

<0.001*

 0–1

45 (8 %)

40 (9.9 %)

5 (2.6 %)

 

 2–4

230 (38 %)

174 (42.9 %)

56 (28.9 %)

 

 5–7

249 (42 %)

153 (37.7 %)

96 (49.5 %)

 

 8+

76 (13 %)

39 (9.6 %)

37 (19.1 %)

 
  1. *statistically significant at p < 0.05; p values refer to differences between cases and controls across all grades