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Table 3 Baseline frequencies of semi-quantitative MRI biomarkers – osteophytes

From: Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort − Methodologic aspects and definition of change

MRI feature

Biomarker

Overall n (%)

Controls

Cases

p-value

Osteophytes

Number of locations affected by any osteophyte

    

 0

19 (3 %)

15 (3.7 %)

4 (2.1 %)

 

 1

34 (6 %)

30 (7.4 %)

4 (2.1 %)

 

 2

42 (7 %)

36 (8.9 %)

6 (3.1 %)

 

 3

58 (10 %)

43 (10.6 %)

15 (7.7 %)

 

 4

54 (9 %)

39 (9.6 %)

15 (7.7 %)

 

 5

47 (8 %)

38 (9.4 %)

9 (4.6 %)

 

 6

45 (8 %)

28 (6.9 %)

17 (8.8 %)

 

 7

37 (6 %)

23 (5.7 %)

14 (7.2 %)

 

 8

49 (8 %)

26 (6.4 %)

23 (11.9 %)

 

 9

41 (7 %)

26 (6.4 %)

15 (7.7 %)

 

 10

47 (8 %)

30 (7.4 %)

17 (8.8 %)

 

 11

48 (8 %)

33 (8.1 %)

15 (7.7 %)

 

 12

79 (13 %)

39 (9.6 %)

40 (20.6 %)

 

Number of locations affected by any osteophyte category

   

<0.001*

 0–2

95 (16 %)

81 (20.0 %)

14 (7.2 %)

 

 3–5

159 (27 %)

120 (29.6 %)

39 (20.1 %)

 

 6+

346 (58 %)

205 (50.5 %)

141 (72.7 %)

 

Max osteophyte score in knee

    

 0

19 (3 %)

15 (3.7 %)

4 (2.1 %)

 

 1

290 (48 %)

209 (51.5 %)

81 (41.8 %)

 

 2

202 (34 %)

132 (32.5 %)

70 (36.1 %)

 

 3

89 (15 %)

50 (12.3 %)

39 (20.1 %)

 
 

Max osteophyte score in knee category

   

0.011*

 0–1

309 (52 %)

224 (55.2 %)

85 (43.8 %)

 
 

 2

202 (34 %)

132 (32.5 %)

70 (36.1 %)

 
 

 3

89 (15 %)

50 (12.3 %)

39 (20.1 %)

 
  1. *statistically significant at p < 0.05; p values refer to differences between cases and controls across all grades