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Table 2 Baseline frequencies of semi-quantitative MRI biomarkers – BMLs

From: Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort − Methodologic aspects and definition of change

MRI feature

Biomarker

Overall n (%)

Controls

Cases

p-value

BML

Number of subregions affected by any BML

    

 0

66 (11 %)

55 (13.5 %)

11 (5.7 %)

 

 1

98 (16 %)

76 (18.7 %)

22 (11.3 %)

 

 2

126 (21 %)

88 (21.7 %)

38 (19.6 %)

 

 3

129 (22 %)

88 (21.7 %)

41 (21.1 %)

 

 4

84 (14 %)

52 (12.8 %)

32 (16.5 %)

 

 5

59 (10 %)

27 (6.7 %)

32 (16.5 %)

 

 6

26 (4 %)

14 (3.4 %)

12 (6.2 %)

 

 7

8 (1 %)

5 (1.2 %)

3 (1.5 %)

 

 8

4 (1 %)

1 (0.2 %)

3 (1.5 %)

 

Number of subregions affected by any BML

   

<0.001*

 0

66 (11 %)

55 (13.5 %)

11 (5.7 %)

 

 1

98 (16 %)

76 (18.7 %)

22 (11.3 %)

 

 2

126 (21 %)

88 (21.7 %)

38 (19.6 %)

 

 3

129 (22 %)

88 (21.7 %)

41 (21.1 %)

 

 4

84 (14 %)

52 (12.8 %)

32 (16.5 %)

 

 5+

97 (16 %)

47 (11.6 %)

50 (25.8 %)

 

Max BML score in knee

   

0.016*

 0

66 (11 %)

55 (13.5 %)

11 (5.7 %)

 

 1

223 (37 %)

148 (36.5 %)

75 (38.7 %)

 

 2

202 (34 %)

138 (34.0 %)

64 (33.0 %)

 

 3

109 (18 %)

65 (16.0 %)

44 (22.7 %)

 
  1. *statistically significant at p < 0.05; p values refer to differences between cases and controls across all grades