Table 10 Twenty-four month change in semi-quantitative MRI biomarkers – cartilage
MRI feature | Biomarker | Overall n (%) | Controls | Cases | p-value |
|---|---|---|---|---|---|
Cartilage | MOAKS Cartilage Morphology - entire knee number of areas with BL to 24 M worsening in thickness | ||||
0 | 348 (58 %) | 266 (65.5 %) | 82 (42.3 %) | ||
1 | 132 (22 %) | 83 (20.4 %) | 49 (25.3 %) | ||
2 | 77 (13 %) | 39 (9.6 %) | 38 (19.6 %) | ||
3 | 34 (6 %) | 13 (3.2 %) | 21 (10.8 %) | ||
4 | 8 (1 %) | 5 (1.2 %) | 3 (1.5 %) | ||
6 | 1 (0 %) | 0 (0.0 %) | 1 (0.5 %) | ||
MOAKS Cartilage Morphology - entire knee number of areas with BL to 24 M worsening in thickness | <0.001 | ||||
No Change | 348 (58 %) | 266 (65.5 %) | 82 (42.3 %) | ||
Worsen in 1 subregion | 132 (22 %) | 83 (20.4 %) | 49 (25.3 %) | ||
Worsen in 2 subregions | 77 (13 %) | 39 (9.6 %) | 38 (19.6 %) | ||
Worsen in 3+ subregions | 43 (7 %) | 18 (4.4 %) | 25 (12.9 %) | ||
MOAKS Cartilage Morphology - entire knee number of areas with BL to 24 M worsening in surface area (include within-grade change) | |||||
0 | 246 (41 %) | 193 (47.5 %) | 53 (27.3 %) | ||
1 | 176 (29 %) | 122 (30.0 %) | 54 (27.8 %) | ||
2 | 91 (15 %) | 52 (12.8 %) | 39 (20.1 %) | ||
3 | 60 (10 %) | 31 (7.6 %) | 29 (14.9 %) | ||
4 | 20 (3 %) | 6 (1.5 %) | 14 (7.2 %) | ||
5 | 5 (1 %) | 2 (0.5 %) | 3 (1.5 %) | ||
6 | 1 (0 %) | 0 (0.0 %) | 1 (0.5 %) | ||
8 | 1 (0 %) | 0 (0.0 %) | 1 (0.5 %) | ||
MOAKS Cartilage Morphology - entire knee number of areas with BL to 24 M worsening in surface area (include within-grade change) | <0.001 | ||||
No Change | 246 (41 %) | 193 (47.5 %) | 53 (27.3 %) | ||
Worsen in 1 subregion | 176 (29 %) | 122 (30.0 %) | 54 (27.8 %) | ||
Worsen in 2 subregions | 91 (15 %) | 52 (12.8 %) | 39 (20.1 %) | ||
Worsen in 3+ subregions | 87 (15 %) | 39 (9.6 %) | 48 (24.7 %) | ||
MOAKS Cartilage Morphology - entire knee number of areas with BL to 24 M worsening in surface area (exclude within-grade change) | |||||
0 | 382 (64 %) | 277 (68.2 %) | 105 (54.1 %) | ||
1 | 128 (21 %) | 87 (21.4 %) | 41 (21.1 %) | ||
2 | 56 (9 %) | 31 (7.6 %) | 25 (12.9 %) | ||
3 | 28 (5 %) | 9 (2.2 %) | 19 (9.8 %) | ||
4 | 3 (1 %) | 2 (0.5 %) | 1 (0.5 %) | ||
5 | 2 (0 %) | 0 (0.0 %) | 2 (1.0 %) | ||
6 | 1 (0 %) | 0 (0.0 %) | 1 (0.5 %) | ||
MOAKS Cartilage Morphology - entire knee number of areas with BL to 24 M worsening in surface area (exclude within-grade change) | <0.001 | ||||
No Change | 382 (64 %) | 277 (68.2 %) | 105 (54.1 %) | ||
Worsen in 1 subregion | 128 (21 %) | 87 (21.4 %) | 41 (21.1 %) | ||
Worsen in 2 subregions | 56 (9 %) | 31 (7.6 %) | 25 (12.9 %) | ||
Worsen in 3+ subregions | 34 (6 %) | 11 (2.7 %) | 23 (11.9 %) |