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Table 1 Inhibition ratios of mRNA levels and protein levels

From: Lentivirus-mediated short hairpin RNA interference targeting TNF-alpha in macrophages inhibits particle-induced inflammation and osteolysis in vitro and in vivo

Particles

mRNA levels mean ± SD

protein levels mean ± SD (pg/ml)

 

Particle

Particle + TNF-LV

Particle + N.C-LV

IRa

Particle

Particle + TNF-LV

Particle + N.C-LV

IRa

TI

24.06 ± 5.06

11.26 ± 3.48

1.50 ± 0.57

53.22 %

780.12 ± 36.36

490.03 ± 8.80

730.06 ± 45.88

37.18 %

CE

9.01 ± 1.49

4.82 ± 0.22

1.50 ± 0.57

46.52 %

572.11 ± 38.41

329.73 ± 17.22

527.11 ± 44.68

42.37 %

  1. aIR (Inhibition ratio) = (mRNA or protein levels of Group Particle minus Group Particle + TNF-LV)/Group Particle. There were no significant differences in RNAi inhibitory effects among titanium and ceramic particle stimulation groups in both mRNA levels and protein levels (P > 0.05)
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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