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Table 4 Appraisal of the evidence

From: Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature

 

Phenotypes

Author/year

Chronic pain

Inflammatory

Metabolic syndrome

Metabolic bone/cartilage

Mechanical overload

Minimal joint disease

Attur 2011 [18]

 

++

    

Bae 2010 [19]

    

++

 

Berry 2010a [20]

   

++

  

Berry 2010b [21]

     

++

Blumnenfeld 2013 [22]

   

++

  

Cruz-Almeida 2013 [23]

++

     

Doss 2007 [24]

 

++

    

Egsgaard 2015 [25]

+

     

Fernández-Tajes 2014 [26]

 

++

    

Holla 2013 [27]

     

++

Jenkins 2015 [28]

     

+

Kerkhof 2008 [29]

      

Kinds 2013 [9]

     

++

King 2013 [30]

+

     

Knoop 2011 [7]

++

 

++

 

++

++

Murphy 2011 [31]

++

     

Otterness 2000 [32]

 

++

 

++

  

Pereira 2013 [33]

++

     

Roemer 2012 [34]

   

++

  

Sowers 2002 [35]

  

++

   

Van der Esch 2015 [36]

++

 

++

 

++

++

Van Spil 2012 [37]

 

++

++

   

Waarsing 2015 [8]

   

++

++

++

Iijima 2015 [38]

    

+

 

Kittelson 2015 [40]

++

     

Total number of studies

6 (2)

5

4

5

4 (1)

6 (1)

  1. + high risk of bias, ++ low risk of bias
  2. Total Number of Studies: low risk of bias (high risk of bias)