Skip to main content

Table 4 Patient-reported severity of adverse events associated with biologic therapies, subcutaneous methotrexate, and oral methotrexate

From: Patient’s experience with subcutaneous and oral methotrexate for the treatment of rheumatoid arthritis

   Severity of hair loss
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 197 (90) 2 (1) 4 (2) 12 (6) 0 (0) 3 (1) 0 (0)
SQ MTX 49 32 (65) 1 (2) 9 (18) 2 (4) 5 (10) 0 (0) 0 (0)
Oral MTX 115 80 (70) 2 (2) 10 (9) 8 (7) 13 (11) 2 (2) 0 (0)
P value for row mean score < 0.0001
P value for row mean score differs (excluding “No” responses) = 0.37
   Severity of diarrhea
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 210 (96) 1 (.5) 1 (.5) 3 (1.5) 1 (.5) 2 (1) 0 (0)
SQ MTX 49 43 (88) 0 3 (6) 0 (0) 2 (4) 1 (2) 0 (0)
Oral MTX 115 89 (77) 2 (2) 9 (8) 11 (10) 1 (1) 3 (2) 0 (0)
P value for row mean score < 0.0001
P value for row mean score differs (excluding “No” responses) = 0.50
   Severity of vomiting
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 210 (96) 0 5 (2) 1 (.5) 1 (.5) 1 (.5) 0 (0)
SQ MTX 49 45 (91) 2 (4) 1 (2) 0 1 (2) 0 (0) 0 (0)
Oral MTX 115 107 (93) 1 (1) 2 (1) 4 (4) 1 (1) 0 (0) 0 (0)
P value for row mean score = 0.63
P value for row mean score differs (excluding “No” responses) = 0.15
   Severity of nausea
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 190 (87) 0 (0) 7 (3) 11 (5) 6 (3) 2 (1) 2 (1)
SQ MTX 49 22 (45) 0 (0) 7 (14) 11 (22) 4 (8) 3 (6) 2 (4)
Oral MTX 115 76 (66) 12 (10) 17 (15) 10 (9) 0 (0) 0 (0) 0 (0)
P value for row mean score < 0.0001
P value for row mean score differs (excluding “No” responses) = 0.21
   Severity of other stomach problems
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 204 (94) 0 (0) 3 (1) 4 (2) 5 (2) 2 (1) 0 (0)
SQ MTX 49 46 (94) 0 (0) 1 (2) 0 0 2 (4) 0 (0)
Oral MTX 115 108 (94) 0 (0) 1 (1) 5 (4) 0 1 (1) 0 (0)
P value for row mean score = 0.87
P value for row mean score differs (excluding “No” responses) = 0.50
   Severity of fatigue
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 170 (78) 1 (.5) 5 (2) 17 (8) 10 (4.5) 13 (6) 2 (1)
SQ MTX 49 13 (27) 0 4 (8) 16 (33) 5 (10) 10 (20) 1 (2)
Oral MTX 115 51 (44) 0 5 (4) 25 (22) 23 (20) 10 (9) 1 (1)
P value for row mean score = <0.0001
P value for row mean score differs (excluding “No” responses) = 0.90
   Severity of malaise
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 187 (86) 2 (1) 3 (1) 13 (6) 9 (4) 3 (1) 1 (1)
SQ MTX 49 26 (53) 1 (2) 4 (8) 12 (24) 5 (10) 1 (2) 0 (0)
Oral MTX 115 77 (67) 0 12 (10) 20 (17) 5 (4) 1 (1) 0 (0)
P value for row mean score = <0.0001
P value for row mean score differs (excluding “No” responses) = 0.09
   Severity of mental fog
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 185 (85) 0 7 (3) 15 (7) 7 (3) 2 (1) 2 (1)
SQ MTX 49 31 (63) 0 4 (8) 11 (22) 3 (6) 0 0 (0)
Oral MTX 115 82 (71) 2 (2) 15 (13) 9 (8) 6 (5) 1 (1) 0 (0)
P value for row mean score = 0.01
P value for row mean score differs (excluding “No” responses) = 0.03
   Severity of infection
Therapy, n (%) N No Trivial Mild Moderate Marked Severe So severe I had to stop
Biologic therapies 218 195 (95) 0 (0) 3 (1) 8 (1) 3 (1) 5 (2) 4 (2)
SQ MTX 49 45 (92) 0 (0) 1 (2) 2 (4) 1 (2) 0 (0) 0 (0)
Oral MTX 115 110 (96) 0 (0) 1 (1) 3 (2) 1 (1) 0 (0) 0 (0)
P value for row mean score = 0.06
P value for row mean score differs (excluding “No” responses) = 0.16