AE, n (%) | Biologics without MTX | Biologics with MTX | SQ MTX | Oral MTX | P value |
---|---|---|---|---|---|
n = 95 | N = 123 | n = 49 | n = 115 | ||
Hair loss | 10 (11) | 11 (9) | 17 (35) | 35 (30) | <0.0001 |
Diarrhea | 2 (2) | 6 (5) | 6 (12) | 26 (23) | <0.0001 |
Vomiting | 2 (2) | 6 (5) | 4 (8) | 8 (7) | 0.32 |
Nausea | 11 (12) | 17 (14) | 27 (55) | 39 (34) | <0.0001 |
Other stomach problems | 9 (10) | 5 (4) | 3 (6) | 7 (6) | 0.44 |
Fatigue | 21 (22) | 27 (22) | 36 (73) | 64 (56) | <0.0001 |
Malaise | 17 (18) | 14 (11) | 23 (47) | 38 (33) | <0.0001 |
Mental fog | 14 (15) | 19 (15) | 18 (37) | 33 (29) | 0.0016 |
Infection | 12 (13) | 11 (9) | 4 (8) | 5 (4) | 0.19 |
Any pain with injections | 48a (89) | 62a (84) | 27 (55) | N/A | <0.0001 |
Side effect sumb | <0.0001 | ||||
0 | 67 (71) | 91 (74) | 5 (10) | 36 (31) | |
1 | 4 (4) | 7 (6) | 9 (18) | 12 (10) | |
2 | 4 (4) | 7 (6) | 7 (14) | 19 (17) | |
3 | 10 (11) | 5 (4) | 12 (24) | 17 (15) | |
4 | 6 (6) | 6 (5) | 8 (16) | 14 (12) | |
> =5 | 4 (4) | 7 (6) | 8 (16) | 17 (15) |