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Table 2 The results of cumulative consumption and VAS score at 24 h and 48 h, NS, not applicable

From: The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis

Variables

Studies (n)

Patients (n)

p-value

Incidence

Mean difference (95 % CI) or risk ratio (95 % CI)

Heterogeneity p-value (I2)

Model

24 h cumulative consumption

 Overall

5

540

<0.001

−7.82 (−0.95, −0.52)

<0.001 (87.2 %)

random

 Gabapentin

3

300

<0.001

−2.65 (−3.67, −1.63)

0.427 (0 %)

random

 Pregabalin

2

240

<0.001

−19.42 (−11.72, −3.93)

<0.001 (59.9 %)

random

48 h cumulative consumption

 Overall

5

378

0.118

−6.90 (−0.95, 0.57)

<0.001 (93.7 %)

random

 Gabapentin

3

258

1.000

0.00 (−7.69, 7.69)

<0.001 (94.5 %)

random

 Pregabalin

2

120

<0.001

−33.02 (−45.86, −20.19)

0.989 (0.00 %)

random

VAS score with rest at 24 h

 Overall

5

451

0.360

0.15 (−0.17, −0.48)

0.017 (63.7 %)

random

 Gabapentin

3

300

0.076

0.32 (−0.03, 0.67)

0.082 (55.3 %)

random

 Pregabalin

2

151

0.486

−3.05 (−11.63, 5.53)

0.193 (41.1 %)

random

VAS score with rest at 48 h

 Overall

3

331

0.363

0.22 (−0.25, 0.69)

0.003 (78 %)

random

 Gabapentin

2

258

0.049

0.41 (0.00, 0.81)

0.072 (62.1 %)

random

 Pregabalin

1

73

0.106

NS

NS

NS

VAS score with mobilization at 24 h

 Overall

5

451

0.164

0.46 (−0.19, 1.11)

<0.001 (91 %)

random

 Gabapentin

3

300

1.137

0.72 (0.23, 1.66)

<0.001 (93.1 %)

random

 Pregabalin

2

151

0.803

−0.78 (−6.91, 5.35)

0.799 (0 %)

random

VAS score with mobilization at 48 h

 Overall

3

331

0.193

1.15 (−0.58, 2.89)

<0.001 (97.8 %)

random

 Gabapentin

2

258

0.045

1.90 (0.04, 3.75)

<0.001 (97.2 %)

random

 Pregabalin

1

73

<0.001

NS

NS

NS