Skip to main content

Table 2 The results of cumulative consumption and VAS score at 24 h and 48 h, NS, not applicable

From: The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis

Variables Studies (n) Patients (n) p-value Incidence
Mean difference (95 % CI) or risk ratio (95 % CI) Heterogeneity p-value (I2) Model
24 h cumulative consumption
 Overall 5 540 <0.001 −7.82 (−0.95, −0.52) <0.001 (87.2 %) random
 Gabapentin 3 300 <0.001 −2.65 (−3.67, −1.63) 0.427 (0 %) random
 Pregabalin 2 240 <0.001 −19.42 (−11.72, −3.93) <0.001 (59.9 %) random
48 h cumulative consumption
 Overall 5 378 0.118 −6.90 (−0.95, 0.57) <0.001 (93.7 %) random
 Gabapentin 3 258 1.000 0.00 (−7.69, 7.69) <0.001 (94.5 %) random
 Pregabalin 2 120 <0.001 −33.02 (−45.86, −20.19) 0.989 (0.00 %) random
VAS score with rest at 24 h
 Overall 5 451 0.360 0.15 (−0.17, −0.48) 0.017 (63.7 %) random
 Gabapentin 3 300 0.076 0.32 (−0.03, 0.67) 0.082 (55.3 %) random
 Pregabalin 2 151 0.486 −3.05 (−11.63, 5.53) 0.193 (41.1 %) random
VAS score with rest at 48 h
 Overall 3 331 0.363 0.22 (−0.25, 0.69) 0.003 (78 %) random
 Gabapentin 2 258 0.049 0.41 (0.00, 0.81) 0.072 (62.1 %) random
 Pregabalin 1 73 0.106 NS NS NS
VAS score with mobilization at 24 h
 Overall 5 451 0.164 0.46 (−0.19, 1.11) <0.001 (91 %) random
 Gabapentin 3 300 1.137 0.72 (0.23, 1.66) <0.001 (93.1 %) random
 Pregabalin 2 151 0.803 −0.78 (−6.91, 5.35) 0.799 (0 %) random
VAS score with mobilization at 48 h
 Overall 3 331 0.193 1.15 (−0.58, 2.89) <0.001 (97.8 %) random
 Gabapentin 2 258 0.045 1.90 (0.04, 3.75) <0.001 (97.2 %) random
 Pregabalin 1 73 <0.001 NS NS NS