Table 1 The general character of the included studies
Clinical trial | Number of patients (G/C) | Mean age (G/C, yr) | Male/Female | anesthesia | Dose of gabapentin | Time to use the pregablin | Intraoperative analgesai | preoperative analgesia | Postoperative analgesics |
|---|---|---|---|---|---|---|---|---|---|
Carmichael et al. [11] | 23/24 | 59.1/61.3 | 22/25 | spinal anesthetic | 75 mg twice per day | 2 weeks preoperative and for 3 weeks from the day of discharge | NS | 400 mg celecoxib, 150 mg pregabalin and 1 g of acetaminophen | * |
Clarke et al. [12] | 83/79 | 60.2/60.1 | 82/80 | spinal anesthesia | 150 mg/day | 2 h before surgery | Hypobaric bupivacaine 0.5 % (10 ml) with fentanyl 10 μg was injected | celecoxib | PCA |
Martinez et al. [14] | 35/38 | 64/64 | 45/28 | general anesthesia | 150 mg/day | before surgery | 0.2 lg.kg 1 sufentanil followed by 2 mg.kg 1 propofol and 0.5 mg.kg 1 | NS | PCA |
Mathiesen et al. [15] | 40/38 | 67/66 | 32/46 | spinal anesthesia | 300 mg/day | 1 h before anesthesia | 3 ml plain bupivacaine 5 mg ml | acetaminophen 1 g was given as premedication 1 h before anesthesia | PCA |
Rasmussen et al. [17] | 24/18 | 72/70 | 18/24 | spinal anesthesia | 1200 mg/day | 1 h before anesthesia | 3 ml plain bupivacaine (5mgml | NS | PCA |
Paul et al. [16] | 48/54 | 60.9/60.5 | 58/64 | spinal anesthesia | 600 mg/day | 2 h before surgery | fentanyl 20 lg and 0.5 % or 0.75 % of bupivacaine | NS | PCA |
Clarke et al. [13] | 78/39 | 58.9/61.3 60.4/61.3 | 49/45 | spinal anesthesia | 600 mg/day | 2 h before surgery | 15 mg of 0.5 % hypobaric bupivacaine with 10 mg of fentanyl | acetaminophen 1000 mg per (p.o.), celecoxib 400 mg p.o. and dexamethasone 8 mg iv | PCA |