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Table 1 The general character of the included studies

From: The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis

Clinical trial Number of patients (G/C) Mean age (G/C, yr) Male/Female anesthesia Dose of gabapentin Time to use the pregablin Intraoperative analgesai preoperative analgesia Postoperative analgesics
Carmichael et al. [11] 23/24 59.1/61.3 22/25 spinal anesthetic 75 mg twice per day 2 weeks preoperative and for 3 weeks from the day of discharge NS 400 mg celecoxib, 150 mg pregabalin and 1 g of acetaminophen *
Clarke et al. [12] 83/79 60.2/60.1 82/80 spinal anesthesia 150 mg/day 2 h before surgery Hypobaric bupivacaine 0.5 % (10 ml) with fentanyl 10 μg was injected celecoxib PCA
Martinez et al. [14] 35/38 64/64 45/28 general anesthesia 150 mg/day before surgery 0.2 lg.kg 1 sufentanil followed by 2 mg.kg 1 propofol and 0.5 mg.kg 1 NS PCA
Mathiesen et al. [15] 40/38 67/66 32/46 spinal anesthesia 300 mg/day 1 h before anesthesia 3 ml plain bupivacaine 5 mg ml acetaminophen 1 g was given as premedication 1 h before anesthesia PCA
Rasmussen et al. [17] 24/18 72/70 18/24 spinal anesthesia 1200 mg/day 1 h before anesthesia 3 ml plain bupivacaine (5mgml NS PCA
Paul et al. [16] 48/54 60.9/60.5 58/64 spinal anesthesia 600 mg/day 2 h before surgery fentanyl 20 lg and 0.5 % or 0.75 % of bupivacaine NS PCA
Clarke et al. [13] 78/39 58.9/61.3 60.4/61.3 49/45 spinal anesthesia 600 mg/day 2 h before surgery 15 mg of 0.5 % hypobaric bupivacaine with 10 mg of fentanyl acetaminophen 1000 mg per (p.o.), celecoxib 400 mg p.o. and dexamethasone 8 mg iv PCA
  1. PCA patient controlled anesthesia, iv intravenous, p.o postoperative, NS not stated
  2. *pregabalin (75 mg twice per day), celecoxib (200 mg twice per day) and acetaminophen (1 g every 6 h) for 5 day