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Table 1 Levels of Bone turnover and inflammatory markers

From: The effects of dopamine receptor 2 expression on B cells on bone metabolism and TNF-α levels in rheumatoid arthritis

 

Control

n = 12

OA

n = 12

RA

n = 14

TNF-α (pg/ml)

10.45 (8.05, 17.33)

14.4 (11.03, 20.58)

16.2 (12.53, 24.00)*

IL-1β (pg/ml)

<5

<5

<5

IL-6 (pg/ml)

2.00 (2.0, 2.38)

2.60 (2.0, 2.70)

9.70 (7.9, 71.95)*,**

IL-17 (pg/ml)

<15

<15

17.99 ± 1.81

ICTP (μg/L)

1.79 (1.59, 2.50)

2.22 (1.68, 3.11)

4.40 (2.98, 5.28)*,**

OC (ng/ml)

17.33 ± 4.43

14.25 ± 4.13

16.33 ± 8.81

β-CTX (ng/ml)

0.33 (0.25, 0.42)

0.47 (0.35, 0.56)*

0.28 (0.19, 0.43)

PINP (ng/ml)

48.07 ± 14.99

53.31 ± 16.73

48.89 ± 21.39

MMP-3 (ng/ml)

12.79 ± 8.17***

5.25 ± 1.95***

29.93 ± 18.57

OPG (pg/ml)

156.14 (151.48, 161.96)

96.45 (87.45, 145.37)*

73.79 (59.88, 89.75)

  1. Continuous data are expressed as means ± standard deviation (SD) or medians (inter-quartile range, IQR) according to the data distribution
  2. Abbreviations: TNF-α tumor necrosis factor-α; IL-1β interleukin-1β, IL-6 interleukin-6, IL-17 interleukin-17, ICTP collagen type I cross-linked telopeptide, OC osteocalcin, PINP procollagen type I N propeptide, β-CTX C-terminal telopeptide of type I collagen, ICTP collagen type I cross-linked telopeptide, MMP3 matrix metalloproteinase 3, OPG osteoprotegerin
  3. *P < 0.05 compared to healthy controls using the Mann–Whitney U-test
  4. ** P < 0.05 compared to the OA group using the Mann–Whitney U-test
  5. ***P < 0.05 compared to the RA pretreatment group using Student’s t-test
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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