Table 4 Mean change from baseline in TSS and subscores plus Larsen Score in the non-DMARD-IR population as estimated with meta-analysis
| Â | Week 12 | Week 24 | Week 52 | Week 104 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
CFB | 95Â % CrI | Probability of deterioration relative to baseline | CFB | 95Â % CrI | Probability of deterioration relative to baseline | CFB | 95Â % CrI | Probability of deterioration relative to baseline | CFB | 95Â % CrI | Probability of deterioration relative to baseline | |
TSS | ||||||||||||
 DMARDs | 1.56 | (0.79, 2.34) | >0.99 | 2.49 | (1.2, 3.79) | >0.99 | 3.91 | (1.16, 6.7) | >0.99 | 5.13 | (−1.35, 11.67) | 0.94 |
 MTXa | 1.07 | (0.62, 1.53) | >0.99 | 1.76 | (1, 2.57) | >0.99 | 2.89 | (1.41, 4.56) | >0.99 | 4.15 | (1.08, 7.63) | >0.99 |
 AZAa | 0.73 | (−0.08, 1.54) | 0.96 | 1.34 | (0.17, 2.52) | 0.99 | 2.57 | (0.86–4.41) | >0.99 | 4.55 | (1.19, 8.26) | >0.99 |
Erosion Subscore | ||||||||||||
 DMARDs | 0.69 | (0.31, 1.12) | >0.99 | 1.07 | (0.5, 1.67) | >0.99 | 1.80 | (0.76, 2.85) | >0.99 | 2.93 | (0.92, 5.02) | >0.99 |
 MTXa | 0.64 | (0.2, 1.07) | >0.99 | 0.99 | (0.32, 1.68) | >0.99 | 1.65 | (0.35, 3.05) | 0.99 | 2.70 | (0.08, 5.53) | 0.98 |
 AZAa | 0.59 | (0.13, 1.03) | 0.99 | 0.88 | (0.17, 1.59) | 0.99 | 1.41 | (0.05, 2.86) | 0.98 | 2.21 | (−0.53, 5.14) | 0.95 |
Joint Space Narrowing Subscore | ||||||||||||
 DMARDs | 0.29 | (0.17, 0.44) | >0.99 | 0.59 | (0.34, 0.88) | >0.99 | 1.28 | (0.73, 1.9) | >0.99 | 2.55 | (1.45, 3.8) | >0.99 |
 MTXa | 0.26 | (0.05, 0.51) | 0.99 | 0.51 | (0.1, 1.02) | 0.99 | 1.11 | (0.22, 2.2) | 0.99 | 2.21 | (0.45, 4.41) | 0.99 |
 AZAa | 0.24 | (0.02, 0.5) | 0.98 | 0.48 | (0.05, 1) | 0.98 | 1.04 | (0.1, 2.17) | 0.98 | 2.08 | (0.21, 4.34) | 0.98 |
(Standardized) Larsen score | ||||||||||||
 DMARDs | 0.08 | (0.04–0.11) | >0.99 | 0.15 | (0.08–0.22) | >0.99 | 0.33 | (0.18–0.48) | >0.99 | 0.65 | (0.36–0.96) | >0.99 |