Table 3 Mean change from baseline in TSS and subscores in the DMARD-IR population as estimated with meta-analysis
| Â | Week 12 | Week 24 | Week 52 | Week 104 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
CFB | 95Â % CrI | Probability of deterioration relative to baseline | CFB | 95Â % CrI | p-value | CFB | 95Â % CrI | Probability of deterioration relative to baseline | CFB | 95Â % CrI | Probability of deterioration relative to baseline | |
TSS | ||||||||||||
 DMARDs | 1.14 | (0.66, 1.67) | >0.99 | 2.27 | (1.31, 3.34) | >0.99 | 4.92 | (2.84, 7.23) | >0.99 | 9.84 | (5.68, 14.46) | >0.99 |
 MTXa | 0.97 | (0.49, 1.52) | 0.99 | 1.95 | (0.98, 3.05) | 0.99 | 4.22 | (2.13, 6.6) | 0.99 | 8.44 | (4.26, 13.21) | 0.99 |
 AZAa | 2.16 | (2.16, 3.04) | >0.99 | 4.32 | (2.59, 6.07) | >0.99 | 9.35 | (5.62, 13.15) | >0.99 | 18.70 | (11.24, 26.31) | >0.99 |
Erosion Subscore | ||||||||||||
 DMARDs | 0.51 | (0.27, 0.83) | 0.99 | 1.02 | (0.55, 1.66) | 0.99 | 2.22 | (1.19, 3.6) | 0.99 | 4.43 | (2.38, 7.21) | 0.99 |
 MTXa | 0.43 | (0.25, 0.69) | 0.98 | 0.87 | (0.49, 1.39) | 0.98 | 1.88 | (1.07, 3.01) | 0.98 | 3.76 | (2.14, 6.01) | 0.98 |
 AZAa | 1.31 | (1.31, 1.98) | >0.99 | 2.62 | (1.3, 3.96) | >0.99 | 5.67 | (2.81, 8.57) | >0.99 | 11.35 | (5.61, 17.14) | >0.99 |
Joint Space Narrowing Subscore | ||||||||||||
 DMARDs | 0.36 | (0.09, 0.67) | 0.99 | 0.72 | (0.18, 1.33) | 0.99 | 1.57 | (0.4, 2.89) | 0.99 | 3.14 | (0.80, 5.78) | 0.90 |