Meta-analysis of long-term joint structural deterioration in minimally treated patients with rheumatoid arthritis

Jansen, Jeroen P.; Vieira, Maria-Cecilia; Bradley, John D.; Cappelleri, Joseph C.; Zwillich, Samuel H.; Wallenstein, Gene V.

doi:10.1186/s12891-016-1195-4

BMC Musculoskeletal Disorders

Table 1 Key study characteristics

From: Meta-analysis of long-term joint structural deterioration in minimally treated patients with rheumatoid arthritis

Study [Ref]	Study design	Follow-up period	Reassignment in studies of biologics	Larsen	JSN	ES	TSS	Outcomes of interest
DMARD-IR population
Breedveld et al. 2004 [20]	RCT	NA	No reassignment; MTX dose increase for non-responders	No	No	No	Yes	Modified TSS
Hamdy et al. 1987 [21]	Double-blind RCT	1.5 years	NA	No	No	No	Yes	TSS
Jeurissen et al. 1991 [22]	Double-blind RCT	48 weeks	NA	No	No	No	Yes	Modified TSS
Keystone et al. 2004 [23]	Double-blind RCT	1 year	No reassignment; MTX dose increase for non-responders	No	Yes	Yes	Yes	Modified TSS
Keystone et al. 2008 [24]	Double-blind RCT	1 year	No reassignment	No	Yes	Yes	Yes	Modified TSS
Lipsky et al. 2000 [25]	RCT	1 year	No reassignment	No	Yes	Yes	Yes	Modified TSS
Maini et al. 2004 [26]	Double-blind RCT	2 years	No reassignment	No	Yes	Yes	Yes	Modified TSS
Sany et al. 1990 [27]	RCT	2 years	NA	Yes	No	No	No	Larsen scores
Smolen et al. 2009 [28]	RCT	2 years	No reassignment	No	Yes	Yes	Yes	Modified TSS
van der Heijde et al. 2006 [29]	Double-blind RCT	2 years	No reassignment	No	Yes	Yes	Yes	Modified TSS
van Holten et al. 2005 [30]	Double-blind RCT	24 weeks	NA	No	No	No	Yes	Modified TSS
Wick et al. 2005 [31]	Retrospective cohort	NA	NA	Yes	No	No	No	Larsen scores
Non-DMARD-IR population
Bathon et al. 2000 [32]	RCT	1 year	No reassignment	No	Yes	Yes	Yes	Modified TSS
Boiardi et al. 1999 [33]	Prospective cohort	1 year	NA	Yes	No	No	No	Larsen scores
Breedveld et al. 2006 [34]	Double-blind RCT	2 years	No reassignment; MTX dose increase for non-responders	No	Yes	Yes	Yes	Modified TSS
Choy et al. 2008 [35]	Double-blind RCT	2 years	NA	Yes	No	No	No	Larsen scores
Cohen et al. 2001 [36]	Double-blind RCT	2 years	NA	No	Yes	Yes	Yes	Modified TSS
Cohen et al. 2008 [37]	Double-blind RCT	1 year	NA	No	Yes	Yes	No	Modified TSS
Emery et al. 2000 [38]	Double-blind RCT	2 years	NA	Yes	No	No	No	Larsen scores
Emery et al. 2008 [39]	Double-blind RCT	1 year	No reassignment	No	No	No	Yes	Modified TSS
Emery et al. 2009 [40]	Double-blind RCT	2 years	No reassignment	No	Yes	Yes	Yes	Modified TSS
Ferraccioli et al. 1996 [41]	Open-label RCT	1 year	NA	Yes	No	No	No	Larsen scores
Ferraccioli et al. 1997 [42]	Open-label RCT	1 year	NA	Yes	No	No	No	Larsen scores
Goldbach-Mansky et al. 2009 [43]	RCT	24 weeks	NA	No	Yes	Yes	Yes	Modified TSS
Hannonen et al. 1993 [44]	Double-blind RCT	48 weeks	NA	No	Yes	Yes	Yes	Modified TSS
Hetland et al. 2006 [45]	Double-blind RCT	1 year	NA	Yes	No	No	No	Larsen scores
Hetland et al. 2008 [46]	Double-blind RCT	2 years	NA	No	Yes	Yes	Yes	Modified TSS
Landewé et al. 2002 [47]	Double-blind RCT	1 year	NA	No	No	No	Yes	Modified TSS
Larsen et al. 2001 [48]	Double-blind RCT	24 weeks	NA	Yes	No	No	No	Larsen scores
Maravic et al. 1999 [49]	Open-label RCT	1 year	NA	Yes	No	No	Yes	Larsen scores and TSS
Marchesoni et al. 2002 [50]	First phase was open and uncontrolled; second phase was single-blind RCT	2 years	NA	Yes	Yes	Yes	Yes	Larsen scores and TSS
Peltomaa et al. 1995 [51]	RCT	1 year	NA	Yes	No	No	No	Larsen scores
Sanmarti et al. 2003 [52]	Prospective cohort	1 year	NA	Yes	No	No	No	Larsen scores
Sarzi-Puttini et al. 2005 [53]	RCT	1 year	NA	Yes	No	No	No	Larsen scores
Scott et al. 1985 [54]	RCT	1 year	NA	Yes	No	No	No	Larsen scores
Scott et al. 1989 [55]	RCT	1 year	NA	Yes	No	No	No	Larsen scores
Scott et al. 1990 [56]	RCT	2 years	NA	Yes	No	No	No	Larsen scores
Smith et al. 1982 [57]	Open-label RCT	2 years	NA	Yes	No	No	No	Larsen scores
St Clair et al. 2004 [58]	RCT	2 years	No reassignment	No	Yes	Yes	Yes	Modified TSS,
Strand et al. 1999 [59]	Double-blind RCT	1 year	NA	No	Yes	Yes	Yes	Modified TSS
Svensson et al. 2003 [60]	Double-blind RCT	1.5 years	NA	Yes	No	No	No	Larsen scores
Svensson et al. 2005 [61]	Open-label RCT	2 years	NA	No	Yes	Yes	Yes	Modified TSS
van Riel et al. 1986 [62]	Single-blind RCT	1 year	NA	Yes	No	No	No	Modified Larsen scores
Wassenberg et al. 2005 [63]	Double-blind RCT	2 years	NA	No	Yes	Yes	Yes	Modified TSS

DMARD disease-modifying anti-rheumatic drug, DMARD-IR patient population with moderate-to-severe RA with a history of inadequate response to non-biologic DMARDs who are currently treated with one (other) non-biologic DMARD, ES Erosion Subscore of TSS, JSN Joint Space Narrowing Subscore of TSS, MTX methotrexate, NA not available, non-DMARD-IR patient population with moderate to severe RA without a history of inadequate response to a DMARD who are currently receiving palliative care (non-steroidal anti-inflammatory drugs, analgesics, low-dose glucocorticoids) or are being minimally treated with one non-biologic DMARD, RA rheumatoid arthritis, Ref reference, RCT randomized controlled trial, TSS modified Total Sharp Score

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