Table 2 Univariate associations with higher than median baseline SF36-Bodily Pain scores in TNFα-inhibitor and non-biologic cohorts

Age

Youngest (ref)

1

1

1

1

Mid

1.06 (0.97 - 1.17)

0.230

1.06 (0.97 - 1.16)

0.203

1.09 (0.91 - 1.30)

0.366

1.04 (0.89 - 1.22)

0.657

Oldest

0.98 (0.89 - 1.07)

0.621

0.99 (0.90 - 1.08)

0.815

1.05 (0.88 - 1.26)

0.617

0.97 (0.83 - 1.14)

0.746

Gender

Male (ref)

1

1

1

1

Female

1.11 (1.01 - 1.21)

0.033

1.10 (1.01 - 1.20)

0.033

1.06 (0.90 - 1.25)

0.504

1.04 (0.90 - 1.20)

0.656

BMI

<25 (ref)

1

1

1

1

25 to <30

1.00 (0.91 - 1.10)

0.961

1.01 (0.92 - 1.10)

0.877

1.06 (0.89 - 1.26)

0.534

1.02 (0.88 - 1.19)

0.816

≥30

1.23 (1.11 - 1.37)

<0.001

1.22 (1.11 - 1.34)

<0.001

1.56 (1.29 - 1.89)

<0.001

1.44 (1.22 - 1.70)

<0.001

Smoking

Never (ref)

1

1

1

1

Ex

1.09 (1.00 - 1.19)

0.052

1.09 (1.00 - 1.18)

0.042

1.34 (1.14 - 1.58)

0.001

1.26 (1.08 - 1.46)

0.003

Current

1.20 (1.08 - 1.33)

<0.001

1.19 (1.08 - 1.31)

0.001

1.58 (1.30 - 1.93)

<0.001

1.54 (1.30 - 1.83)

<0.001

DAS28

Lowest (ref)

1

1

1

1

Mid

1.49 (1.34 - 1.65)

<0.001

1.49 (1.35 - 1.65)

<0.001

2.00 (1.65 - 2.42)

<0.001

2.03 (1.72 - 2.39)

<0.001

Highest

2.94 (2.65 - 3.25)

<0.001

2.91 (2.64 - 3.21)

<0.001

4.26 (3.48 - 5.20)

<0.001

3.99 (3.37 - 4.72)

<0.001

DAS28-P

Lowest (ref)

1

1

1

1

Mid

1.50 (1.36 - 1.66)

<0.001

1.48 (1.35 - 1.63)

<0.001

2.03 (1.67 - 2.48)

<0.001

1.97 (1.67 - 2.33)

<0.001

Highest

1.63 (1.47 - 1.80)

<0.001

1.62 (1.47 - 1.78)

<0.001

2.45 (2.00 - 2.99)

<0.001

2.58 (2.17 - 3.05)

<0.001

ESR

Lowest (ref)

1

1

1

1

Mid

1.35 (1.22 - 1.50)

<0.001

1.34 (1.22 - 1.47)

<0.001

1.27 (1.05 - 1.53)

0.012

1.21 (1.03 - 1.42)

0.020

Highest

1.85 (1.68 - 2.05)

<0.001

1.81 (1.65 - 1.99)

<0.001

1.84 (1.52 - 2.22)

<0.001

1.69 (1.44 - 1.98)

<0.001

SJC

Lowest (ref)

1

1

1

1

Mid

1.09 (0.98 - 1.20)

0.100

1.08 (0.98 - 1.18)

0.106

1.24 (1.03 - 1.48)

0.023

1.19 (1.01 - 1.40)

0.037

Highest

1.27 (1.16 - 1.40)

<0.001

1.28 (1.17 - 1.40)

<0.001

1.50 (1.26 - 1.79)

<0.001

1.51 (1.29 - 1.76)

<0.001

VAS-GH

Lowest (ref)

1

1

1

1

Mid

1.81 (1.63 - 2.01)

<0.001

1.83 (1.66 - 2.02)

<0.001

2.64 (2.19 - 3.18)

<0.001

2.66 (2.25 - 3.15)

<0.001

Highest

5.21 (4.69 - 5.78)

<0.001

4.89 (4.44 - 5.40)

<0.001

5.45 (4.48 - 6.63)

<0.001

5.28 (4.44 - 6.28)

<0.001

TJC

Lowest (ref)

1

1

1

1

Mid

1.35 (1.22 - 1.49)

<0.001

1.34 (1.22 - 1.47)

<0.001

1.55 (1.29 - 1.85)

<0.001

1.63 (1.39 - 1.91)

<0.001

Highest

1.91 (1.73 - 2.11)

<0.001

1.91 (1.74 - 2.10)

<0.001

3.13 (2.58 - 3.78)

<0.001

3.01 (2.61 - 3.65)

<0.001

Duration

Shortest (ref)

1

1

1

1

Mid

0.98 (0.89 - 1.08)

0.696

0.99 (0.90 - 1.08)

0.799

1.25 (1.05 - 1.50)

0.015

1.15 (0.98 - 1.35)

0.088

Longest

1.03 (0.93 - 1.13)

0.612

1.03 (0.95 - 1.13)

0.479

1.34 (1.12 - 1.60)

0.002

1.25 (1.07 - 1.47)

0.006

Serology

Seronegative (ref)

1

1

1

1

Seropositive

1.08 (0.99 - 1.17)

0.072

1.07 (0.99 - 1.16)

0.071

1.09 (0.94 - 1.26)

0.246

1.04 (0.91 - 1.19)

0.545

Erosions

None (ref)

1

1

1

1

At baseline

0.97 (0.91 - 1.06)

0.426

0.97 (0.90 - 1.05)

0.450

1.01 (0.88 - 1.17)

0.882

0.99 (0.87 - 1.13)

0.947

Extra-articular manifestation

No (ref)

1

1

1

1

Yes

1.16 (1.09 - 1.27)

<0.001

1.16 (1.07 - 1.26)

<0.001

1.16 (0.96 - 1.39)

0.120

1.18 (1.00 - 1.40)

0.053

Co-morbidity

No (ref)

1

1

1

1

Yes

1.30 (1.19 - 1.38)

<0.001

1.28 (1.19 - 1.38)

<0.001

1.56 (1.34 - 1.81)

<0.001

1.52 (1.32 - 1.74)

<0.001

HAQ

Lowest (ref)

1

1

1

1

Mid

0.98 (0.89 - 1.08)

0.682

0.99 (0.91 - 1.09)

0.870

5.04 (4.09 - 6.22)

<0.001

4.55 (3.80 - 5.44)

<0.001

Highest

1.10 (0.99 - 1.21)

0.068

1.05 (0.96 - 1.15)

0.329

19.44 (15.38 - 24.56)

<0.001

16.30 (13.31 - 19.95)

<0.001

SF36-Vitality

Best (ref)

1

1

1

1

Mid

1.83 (1.64 - 2.05)

<0.001

1.86 (1.68 - 2.06)

<0.001

3.19 (2.61 - 3.90)

<0.001

2.99 (2.51 - 3.56)

<0.001

Worst

5.61 (5.05 - 6.22)

<0.001

5.31 (4.82 - 5.86)

<0.001

8.89 (7.25 - 10.89)

<0.001

8.35 (6.97 - 10.00)

<0.001

SF36-Mental Health

Best (ref)

1

1

1

1

Mid

1.92 (1.73 - 2.14)

<0.001

1.96 (1.78 - 2.17)

<0.001

2.87 (2.37 - 3.48)

<0.001

2.65 (2.24 - 3.12)

<0.001

Worst

4.39 (3.98 - 4.85)

<0.001

4.35 (3.96 - 4.78)

<0.001

7.03 (5.71 - 8.67)

<0.001

5.65 (4.75 - 6.71)

<0.001

SF36-Physical Function

Best (ref)

1

1

1

1

Mid

2.70 (2.41 - 3.01)

<0.001

2.55 (2.29 - 2.81)

<0.001

3.35 (2.75 - 4.09)

<0.001

3.05 (2.56 - 3.64)

<0.001

Worst

9.29 (8.32 - 10.38)

<0.001

8.17 (7.38 - 9.05)

<0.001

16.53 (13.13 - 20.81)

<0.001

12.84 (10.60 - 15.56)

<0.001

Steroids

Not (ref)

1

1

1

1

At baseline

1.28 (1.17 - 1.39)

<0.001

1.25 (1.16 - 1.35)

<0.001

1.44 (1.21 - 1.71)

<0.001

1.44 (1.23 - 1.68)

<0.001

Methotrexate

Not (ref)

1

1

1

1

At baseline

0.77 (0.71 - 0.84)

<0.001

0.75 (0.69 - 0.82)

<0.001

0.92 (0.79 - 1.07)

0.276

0.92 (0.80 - 1.05)

0.210

Sulphasalazine

Not (ref)

1

1

1

1

At baseline

0.86 (0.77 - 0.96)

0.007

0.86 (0.78 - 0.96)

0.006

0.88 (0.75 - 1.03)

0.104

0.84 (0.73 - 0.96)

0.012

Lefunomide

Not (ref)

1

1

1

1

At baseline

1.01 (0.88 - 1.17)

0.882

0.99 (0.86 - 1.14)

0.942

1.50 (1.20 - 1.87)

<0.001

1.48 (1.21 - 1.80)

<0.001

Azathioprine

Not (ref)

1

1

1

1

At baseline

1.03 (0.79 - 1.35)

0.836

1.04 (0.80 - 1.34)

0.796

1.85 (1.12 - 3.08)

0.018

1.79 (1.12 - 2.86)

0.016

Hydroxychloroquine

Not (ref)

1

1

1

1

At baseline

0.89 (0.78 - 1.02)

0.100

0.90 (0.79 - 1.02)

0.094

0.89 (0.73 - 1.09)

0.280

0.94 (0.78 - 1.13)

0.519

Gold

Not (ref)

1

1

1

1

At baseline

1.06 (0.77 - 1.44)

0.750

1.01 (0.75 - 1.37)

0.941

1.77 (1.24 - 2.52)

0.002

1.62 (1.18 - 2.21)

0.002