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Table 6 Molecular findings

From: The pathophysiology associated with primary (idiopathic) frozen shoulder: A systematic review

  

Bunker [39]

Kilian et al. [33]

Lho et al. [19]

Uhthoff and Boileau [41]

Xu et al. [37]

Techniques used

IHC

 

X

X

X

X

ICC

X

    

RTPCR

 

X

X

  

ELISA

  

X

  

Matrix components

Fibroblasts

↑

↓

 

↑

 

Myofibroblasts

↑

↓

   

Cytokines

IL- 1α

  

↑

  

IL-1β

  

↑

  

IL-6

  

↑

  

TNF-α

  

↑

  

Immune factors

Leukocytes

↓

    

Macrophages

↓

    

Neuronal factors

PGP9.5

    

↑

GAP43

    

↑

P75

    

↑

Vascular factors

CD34

    

↑

Enzymes

COX1

  

↑

  

COX2

  

↑

  
  1. ↑ (increased), ↓ (decreased), IHC (immunohistochemistry analysis), ICC (immunocytochemical examination), RTPCR (real time reverse transcription-polymerase chain reaction), ELISA (enzyme-linked immunosorbent assay), IL-1α (interleukin 1 alpha), IL-1β (interleukin 1 beta), IL-6 (interleukin 6), TNF-α (tumour necrosis factor alpha), PGP9.5 (polyclonal rabbit antiprotein gene product 9.5), GAP43 (monoclonal mouse antigrowth-associated protein 43), P75 (nerve growth factor receptor p75), CD34 (monoclonal mouse antihuman CD34), COX1 (cyclooxygenase 1), COX 2 (cyclooxygenase 2)
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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