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Table 4 Incidence rates (95 % CI) of severe adverse events among RA patients

From: Drug retention and safety of TNF inhibitors in elderly patients with rheumatoid arthritis

System organ class allocation

Total (838 PYs)

Elderly patients (212 PYs)

Younger patients (626 PYs)

IRR (elderly patient/younger patients)

Total

5.37 (3.92 – 7.19)

6.13 (3.27 – 10.49)

5.11 (3.50 – 7.22)

1.20 (0.63–2.29)

 General disorders

0.12 (0.00 – 0.66)

0.47 (0.01 – 2.63)

–

 

 Hypersensitivity

0.24 (0.03 – 0.86)

–

0.32 (0.04 – 1.15)

 

 Hepatobiliary disorders

0.48 (0.13 – 1.22)

0.47 (0.01 – 2.63)

0.48 (0.10 – 1.40)

0.98 (0.10–9.46)

 Infections

2.39 (1.46 – 3.69)

2.36 (0.77 – 5.50)

2.40 (1.34 – 3.95)

0.98 (0.36–2.71)

 Injury

0.60 (0.19 – 1.39)

0.94 (0.11 – 3.41)

0.48 (0.10 – 1.40)

1.97 (0.33–11.78)

 Musculoskeletal and connective tissue disorders

0.24 (0.03 – 0.86)

–

0.32 (0.04 – 1.15)

 

 Malignant

0.95 (0.41 – 1.88)

0.94 (0.11 – 3.41)

0.96 (0.35 – 2.09)

0.98 (0.20–4.88)

 Nervous system disorders

0.12 (0.00 – 0.66)

0.47 (0.01 – 2.36)

–

 

 Respiratory, thoracic, and mediastinal disorders

0.24 (0.03 – 0.86)

0.47 (0.01 – 2.36)

0.16 (0.00 – 0.89)

2.95 (0.18–47.21)

  1. CI confidence interval, RA rheumatoid arthritis, PYs patient–years, IRR incidence rate ratio. Values are Incidence per 100 PYs
  2. Bold means statistical significant at the p < 0.05