Table 3 Association of the rs1137101 polymorphism of LEPR gene with risk of knee OA with stratifications by age, gender and K/L grades

All patients (n = 587) versus all controls (n = 628)

1.58

1.09—2.30

0.016

1.20

0.95—1.50

0.12

1.21

1.03—1.44

0.024

Gender groups

 Male (124 patients vs. 143controls)

0.82

0.52—1.28

0.33

1.13

0.44—2.56

0.71

0.90

0.55—1.36

0.46

 Female (453 patients vs. 485 controls)

1.89

1.25—2.87

0.008

1.28

0.85—1.75

0.53

1.56

1.08—2.49

0.012

Age groups

 ≤65 years (285 patients vs. 278 controls)

1.48

1.18—2.36

0.028

0.95

0.68—1.32

0.65

1.26

1.04—1.58

0.045

 >65 years (302 patients vs. 350 controls)

1.72

1.13—2.53

0.020

1.13

0.84—1.56

0.18

1.38

1.13—1.57

0.037

K/L grading groups

 Mild OA (292 patients vs. 628 controls)

1.53

1.05—2.47

0.022

1.08

0.86—1.29

0.31

1.30

1.05—1.62

0.013

 Severe OA (295 patients vs. 628 controls)

1.05

0.67—1.64

0.84

0.95

0.70—1.30

0.73

0.98

0.78—1.25

0.91