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Table 3 Association of the rs1137101 polymorphism of LEPR gene with risk of knee OA with stratifications by age, gender and K/L grades

From: Association of rs1137101 polymorphism in LEPR and susceptibility to knee osteoarthritis in a Northwest Chinese Han population

Groups compared GG + GA versus AA GG versus AG + AA G allele versus A allele
OR 95 % CI P-value OR 95 % CI P-value OR 95 % CI P-value
All patients (n = 587) versus all controls (n = 628) 1.58 1.09—2.30 0.016 1.20 0.95—1.50 0.12 1.21 1.03—1.44 0.024
Gender groups          
 Male (124 patients vs. 143controls) 0.82 0.52—1.28 0.33 1.13 0.44—2.56 0.71 0.90 0.55—1.36 0.46
 Female (453 patients vs. 485 controls) 1.89 1.25—2.87 0.008 1.28 0.85—1.75 0.53 1.56 1.08—2.49 0.012
Age groups          
 ≤65 years (285 patients vs. 278 controls) 1.48 1.18—2.36 0.028 0.95 0.68—1.32 0.65 1.26 1.04—1.58 0.045
 >65 years (302 patients vs. 350 controls) 1.72 1.13—2.53 0.020 1.13 0.84—1.56 0.18 1.38 1.13—1.57 0.037
K/L grading groups          
 Mild OA (292 patients vs. 628 controls) 1.53 1.05—2.47 0.022 1.08 0.86—1.29 0.31 1.30 1.05—1.62 0.013
 Severe OA (295 patients vs. 628 controls) 1.05 0.67—1.64 0.84 0.95 0.70—1.30 0.73 0.98 0.78—1.25 0.91
  1. OR odds ratio, CI conidence interval; vs. versus
  2. AA, AG, and GG genotypes were grouped together and a 2 × 3 contingency-table analysis was performed