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Table 7 Comparison of anthropometric, clinical and densitometric variables between patients with AS taking or not TNF inhibitors

From: Is there a relation between pre-sarcopenia, sarcopenia, cachexia and osteoporosis in patients with ankylosing spondylitis?

 

AS patients not taking TNFi N = 45

AS patients taking TNFi N = 22

P

Age (yrs): m (SD)

39.5 (11.4)

43.7 (11.5)

NS

Height (m): m (SD)

1.73 (0.06)

1.70 (0.06)

NS

Weight (kg): m (SD)

70.6 (14.2)

76.7 (13.3)

NS

BMI (kg/m2): m (SD)

23.3 (4.5)

25.7 (4.2)

NS

Disease duration (yrs): m (SD)

6.8 (6.0)

14.1 (8.9)

0.0001

FFMI: m (SD)

16.3 (1.8)

16.2 (2.0)

NS

FMI: m (SD)

5.9 (3.3)

9.0 (3.5)

0.001

Pre-sarcopenia as defined by Baumgartner : n (%)

23 (51.1)

11 (50.0)

NS

Sarcopenia as defined by EWGSOP: n (%)

12 (27.3)

9 (40.9)

NS

Cachexia as defined by IWSG : n (%)

7 (15.6)

1 (4.5)

NS

LS BMD (g/cm2): m (SD)

1.08 (0.19)

1.19 (0.19)

0.029

LS T-score: m (SD)

−0.90 (1.6)

−0.07 (1.3)

0.034

TH BMD(g/cm2): m (SD)

0.986 (0.18)

0.945 (0.13)

NS

TH T-score: m (SD)

−0.50(1.1)

−0.70 (1.0)

NS

Osteoporosis: n (%)

10 (22.2)

1 (4.5)

NS

BASDAI: m (SD)

3.7 (2.3)

3.6 (2.8)

NS

BASMI: m (SD)

2.7 (52.5)

3.0 (2.5)

NS

BASFI: m (SD)

39.5 (29.8)

41.0 (28.8)

NS

Hand grip strength (kg): m (SD)

23.1 (9.2)

23.1 (9.1)

NS

Get-up and go test (sec): m (SD)

3.4 (0.5)

2.0 (0.5)

NS

Arm circumference (cm): m (SD)

28.0 (3.3)

29.9 (3.8)

NS

Waist circumference (cm): m (SD)

88.3 (12.2)

97.5 (10.7)

0.004

MNA test: m (SD)

0.33 (0.4)

0.09 (0.2)

0.015

SASSS: m (SD)

11.6 (18.8)

7.0 (5.2)

NS

CRP (mg/l): m (SD)

17.0 (30.2)

11.3 (9.9)

NS

ESR (mm/h): m (SD)

29.3 (23.1)

22.3 (15.1)

NS

  1. BMI body mass index, BMD: bone mineral density, CRP: C-reactive protein, ESR erythrocyte sedimentation rate, LS lumbar spine, MNA Mini Nutritional Assessment, SASSS Stoke Ankylosing Spondylitis Spinal Score, TH total hip