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Table 4 Mean differences from placebo (standard error) in fasting glucose, fasting insulin, triglycerides, and adiponectin

From: Safety and pharmacodynamic dose response of short-term prednisone in healthy adult subjects: a dose ranging, randomized, placebo-controlled, crossover study

Parameter Day Prednisone (mg/day)
2.5 5 10 20 40 60
Fasting glucose, mg/dL 1 1.19 (1.97) 3.44 (1.97) 1.60 (1.97) 0.94 (1.96) 1.86 (1.99) 2.13 (1.93)
8 −2.06 (2.00) −1.40 (2.00) −2.11 (2.00) −3.24 (1.99) −6.66 (2.01)** −7.10 (1.97)**
Fasting insulin, μU/mL 1 2.15 (2.90) 2.24 (2.81) 1.69 (2.90) 2.10 (2.89) 1.21 (2.83) 1.76 (2.90)
8 −1.44 (2.34) −1.70 (2.34) −0.52 (2.34) −0.39 (2.32) −0.50 (2.34) 0.71 (2.31)
Triglycerides, mg/dL 1 39.19 (21.19) 17.93 (20.20) 22.60 (21.16) 85.79 (21.12)** 44.56 (20.52)* 37.18 (21.16)
8 5.43 (17.01) 13.56 (16.95) 8.82 (17.01) 9.66 (16.95) 35.59 (17.09)* 26.42 (16.76)
Adiponectin, μg/mL 1 −1.51 (0.69)* −1.61 (0.67)* −0.47 (0.69) −1.89 (0.69)* −0.73 (0.68) −0.18 (0.69)
8 −0.27 (0.58) −0.63 (0.58) 0.02 (0.58) 1.00 (0.58) 2.46 (0.58)** 2.47 (0.57)**
  1. *P ≤ 0.05, **P ≤ 0.01 versus placebo