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Table 4 Mean differences from placebo (standard error) in fasting glucose, fasting insulin, triglycerides, and adiponectin

From: Safety and pharmacodynamic dose response of short-term prednisone in healthy adult subjects: a dose ranging, randomized, placebo-controlled, crossover study

Parameter

Day

Prednisone (mg/day)

2.5

5

10

20

40

60

Fasting glucose, mg/dL

1

1.19 (1.97)

3.44 (1.97)

1.60 (1.97)

0.94 (1.96)

1.86 (1.99)

2.13 (1.93)

8

−2.06 (2.00)

−1.40 (2.00)

−2.11 (2.00)

−3.24 (1.99)

−6.66 (2.01)**

−7.10 (1.97)**

Fasting insulin, μU/mL

1

2.15 (2.90)

2.24 (2.81)

1.69 (2.90)

2.10 (2.89)

1.21 (2.83)

1.76 (2.90)

8

−1.44 (2.34)

−1.70 (2.34)

−0.52 (2.34)

−0.39 (2.32)

−0.50 (2.34)

0.71 (2.31)

Triglycerides, mg/dL

1

39.19 (21.19)

17.93 (20.20)

22.60 (21.16)

85.79 (21.12)**

44.56 (20.52)*

37.18 (21.16)

8

5.43 (17.01)

13.56 (16.95)

8.82 (17.01)

9.66 (16.95)

35.59 (17.09)*

26.42 (16.76)

Adiponectin, μg/mL

1

−1.51 (0.69)*

−1.61 (0.67)*

−0.47 (0.69)

−1.89 (0.69)*

−0.73 (0.68)

−0.18 (0.69)

8

−0.27 (0.58)

−0.63 (0.58)

0.02 (0.58)

1.00 (0.58)

2.46 (0.58)**

2.47 (0.57)**

  1. *P ≤ 0.05, **P ≤ 0.01 versus placebo