Fig. 8

Representative radiographs of untreated and treated femora in rabbits with a critical-sized bone defect. Rabbits that received a 10 mm-long bone defect at the middle of the femur were untreated or treated with autograft bone or BOX hydrogels loaded with different concentrations of BMP-2. The untreated and treated femora at 4, 8 and 12 weeks after operation were examined by X-ray radiography. Red arrows indicate bony defect sites at the femur, and yellow arrows show bridging callus