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Table 3 Bone marrow lesion changes between interim visits

From: Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial

  

100 μg cohort (n = 56) Mean (95 % CI)

Matched placebo (n = 18) Mean (95 % CI)

p - value

Whole knee

Baseline

3.3 (2.5, 4.1)

3.3 (1.4, 5.2)

0.642

 

Delta sum

   
 

 0 to 3 months

−0.02 (−0.38, 0.34)

−0.17 (−0.85, 0.52)

0.682

 

 3 to 6 months

−0.04 (−0.41, 0.34)

−0.06 (−0.37, 0.26)

0.933

 

 6 to 12 months

−0.14 (−0.54, 0.26)

0.44 (−0.15, 1.04)

0.054

 

Delta subregion

   
 

 0 to 3 months

0.02 (−0.28, 0.32)

−0.22 (−0.87, 0.43)

0.597

 

 3 to 6 months

−0.05 (−0.37, 0.27)

−0.06 (−0.37, 0.26)

0.911

 

 6 to 12 months

−0.14 (−0.48, 0.19)

0.44 (−0.15, 1.04)

0.042*

LTFJ

Baseline

0.7 (0.3, 1.1)

0.7 (0.0, 1.4)

0.981

 

Delta sum

   
 

 0 to 3 months

0.04 (−0.12, 0.19)

0.00 (−0.17, 0.17)

0.859

 

 3 to 6 months

0.13 (−0.11, 0.36)

−0.11 (−0.40, 0.18)

0.155

 

 6 to 12 months

−0.13 (−0.39, 0.14)

0.22 (−0.10, 0.54)

0.062

 

Delta subregion

   
 

 0 to 3 months

0.04 (−0.12, 0.19)

0.00 (−0.17, 0.17)

0.859

 

 3 to 6 months

0.09 (−0.12, 0.30)

−0.11 (−0.40, 0.18)

0.155

 

 6 to 12 months

−0.05 (−0.27, 0.16)

0.22 (−0.10, 0.54)

0.064

MTFJ

Baseline

1.6 (1.1, 2.2)

1.1 (0.3, 1.9)

0.418

 

Delta sum

   
 

 0 to 3 months

−0.11 (−0.41, 0.20)

−0.11 (−0.49, 0.27)

0.727

 

 3 to 6 months

−0.07 (−0.27, 0.13)

0.06 (−0.21, 0.32)

0.530

 

 6 to 12 months

0.07 (−0.21, 0.35)

0.17 (−0.38, 0.71)

0.673

 

Delta subregion

   
 

 0 to 3 months

−0.07 (−0.30, 0.16)

−0.17 (−0.47, 0.14)

0.574

 

 3 to 6 months

−0.05 (−0.21, 0.10)

0.06 (−0.21, 0.32)

0.525

 

 6 to 12 months

0.02 (−0.20, 0.24)

0.17 (−0.38, 0.71)

0.646

PFJ

Baseline

1.0 (0.5, 1.5)

1.5 (0.1, 2.9)

1.000

 

Delta sum

   
 

 0 to 3 months

0.05 (−0.09, 0.20)

−0.06 (−0.45, 0.34)

0.772

 

 3 to 6 months

−0.09 (−0.24, 0.06)

0.00 (−0.24, 0.24)

0.647

 

 6 to 12 months

−0.09 (−0.31, 0.13)

0.06 (−0.38, 0.49)

0.123

 

Delta subregion

   
 

 0 to 3 months

0.05 (−0.09, 0.20)

−0.06 (−0.45, 0.34)

0.772

 

 3 to 6 months

−0.09 (−0.24, 0.06)

0.00 (−0.24, 0.24)

0.647

 

 6 to 12 months

−0.11 (−0.32, 0.10)

0.06 (−0.38, 0.49)

0.115

  1. CI confidence interval, LTFJ lateral tibio-femoral joint (includes 5 subregions), MTFJ medial tibio-femoral joint (includes 5 subregions), PFJ patello-femoral joint (includes 4 subregions). Possible score range for bone marrow lesion is 0–3 for each subregion at baseline, 3-, 6- and 12-month
  2. *Statistically significant at p ≤ 0.05