TY - JOUR AU - Roemer, Frank W. AU - Aydemir, Aida AU - Lohmander, Stefan AU - Crema, Michel D. AU - Marra, Monica Dias AU - Muurahainen, Norma AU - Felson, David T. AU - Eckstein, Felix AU - Guermazi, Ali PY - 2016 DA - 2016/07/09 TI - Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial JO - BMC Musculoskeletal Disorders SP - 267 VL - 17 IS - 1 AB - A recent publication on efficacy of Sprifermin for knee osteoarthritis (OA) using quantitatively MRI-defined central medial tibio-femoral compartment cartilage thickness as the structural primary endpoint reported no statistically significant dose response. However, Sprifermin was associated with statistically significant, dose-dependent reductions in loss of total and lateral tibio-femoral cartilage thickness. Based on these preliminary promising data a post-hoc analysis of secondary assessment and endpoints was performed to evaluate potential effects of Sprifermin on semi-quantitatively evaluated structural MRI parameters. Aim of the present analysis was to determine effects of sprifermin on several knee joint tissues over a 12 month period. SN - 1471-2474 UR - https://doi.org/10.1186/s12891-016-1128-2 DO - 10.1186/s12891-016-1128-2 ID - Roemer2016 ER -