From: Body size from birth to middle age and the risk of hip and knee replacement
At birth (kg) | Relative size at age 10 years | Relative size at age 20 years | BMI (kg/m2) at about age 60 years | Total | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<2.5 | 2.5- < 3.5 | 3.5+ | Thin | Average | Plump | Small | Medium | Large | <25 | 25- < 30 | 30+ | ||
Age (years) at baseline, mean (SD) | 59.4 (4.8) | 59.0 (4.8) | 59.2 (4.9) | 59.7 (4.9) | 59.6 (5.0) | 58.7 (4.8) | 59.1 (4.8) | 59.6 (4.9) | 59.8 (5.1) | 59.4 (5.0) | 59.7 (4.9) | 59.4 (4.8) | 59.5 (4.9) |
BMI (kg/m2) at baseline, mean (SD) | 26.4 (4.9) | 26.0 (4.5) | 26.4 (4.8) | 25.5 (4.3) | 25.9 (4.3) | 28.0 (5.5) | 24.5 (3.7) | 25.6 (3.9) | 28.3 (5.3) | 22.5 (1.7) | 27.1 (1.4) | 33.9 (3.8) | 26.1 (4.6) |
Highest socioeconomic tertile, % (N) | 31.7 (19,115) | 35.0 (84,935) | 34.2 (50,239) | 32.5 (80,151) | 34.4 (143,760) | 32.2 (37,814) | 34.6 (81,086) | 34.4 (103,215) | 31.3 (76,102) | 36.5 (131,033) | 32.8 (96,469) | 26.7 (35,213) | 33.5 (262,715) |
Height (cm), mean (SD) | 160.2 (6.7) | 162.1 (6.5) | 163.9 (6.6) | 162.6 (6.9) | 162.2 (6.5) | 161.9 (6.7) | 159.9 (6.2) | 162.4 (6.3) | 164.3 (6.8) | 163.3 (6.5) | 161.7 (6.4) | 160.6 (7.0) | 162.3 (6.7) |
Current smoker, % (N) | 12.4 (7,396) | 11.3 (27,134) | 12.1 (17,638) | 10.6 (25,924) | 12.3 (50,908) | 14.8 (17,231) | 12.9 (29,910) | 11.8 (34,998) | 11.9 (28,713) | 13.8 (49,008) | 11.3 (33,025) | 9.5 (12,397) | 12.2 (94,430) |
Alcohol (drinks pw), mean (SD) | 4.8 (10.3) | 5.4 (9.6) | 5.4 (9.7) | 5.1 (10.0) | 5.2 (9.7) | 5.1 (9.9) | 5.6 (10.1) | 5.4 (10.0) | 4.5 (9.4) | 5.7 (10.0) | 5.1 (9.9) | 3.8 (9.1) | 5.2 (9.9) |
Strenuous exercise > once a week, % (N) | 22.2 (13,051) | 23.8 (56,974) | 23.9 (34,562) | 22.1 (53,342) | 23.3 (95,787) | 22.5 (25,977) | 23.7 (54,594) | 23.4 (68,989) | 21.2 (50,630) | 27.0 (95,066) | 21.0 (60,546) | 15.7 (20,217) | 22.8 (175,829) |
Birth weight (kg), mean (SD) | 2.0 (0.4) | 3.1 (0.3) | 4.0 (0.4) | 3.1 (0.7) | 3.3 (0.7) | 3.4 (0.7) | 3.1 (0.7) | 3.2 (0.7) | 3.3 (0.7) | 3.2 (0.7) | 3.2 (0.7) | 3.2 (0.8) | 3.2 (0.7) |
Menarche age <12 years, % (N) | 24.0 (14,352) | 21.1 (50,852) | 21.5 (31,243) | 24.0 (14,352) | 21.1 (50,852) | 21.5 (31,243) | 17.3 (40,198) | 19.2 (56,937) | 25.0 (60,318) | 15.9 (56,446) | 21.8 (63,599) | 29.8 (38,896) | 20.4 (158,941) |
Parity, mean (SD) | 2.1 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.0 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.1 (1.2) | 2.0 (1.2) | 2.1 (1.2) | 2.3 (1.3) | 2.1 (1.2) |
Ever user of HRT, % (N) | 54.8 (32,621) | 55.5 (133,676) | 54.8 (79,749) | 57.2 (139,309) | 52.8 (218,500) | 52.9 (61,613) | 59.3 (137,799) | 54.3 (161,254) | 49.2 (118,236) | 55.2 (196,036) | 54.5 (158,706) | 50.9 (66,406) | 54.2 (421,148) |
Women, (N) | 60,728 | 244,507 | 147,792 | 248,149 | 420,954 | 118,428 | 236,233 | 302,100 | 245,081 | 361,418 | 296,682 | 132,934 | 791,034 |
Hip replacement | |||||||||||||
Cases (N) | 1,338 | 5,129 | 3,258 | 4,918 | 9,346 | 3,063 | 3,529 | 6,261 | 7,424 | 6,273 | 7,056 | 4,073 | 17,402 |
Followup (years), mean (SD) | 8.6 (2.1) | 8.6 (2.0) | 8.6 (2.0) | 8.6 (2.0) | 8.6 (2.1) | 8.6 (2.1) | 8.6 (2.0) | 8.6 (2.1) | 8.6 (2.1) | 8.7 (2.0) | 8.6 (2.1) | 8.5 (2.1) | 8.6 (2.1) |
Knee replacement | |||||||||||||
Cases (N) | 1,537 | 5,283 | 3,420 | 6,061 | 9,187 | 2,970 | 3,621 | 5,953 | 8,525 | 3,532 | 7,395 | 7,370 | 18,297 |
Followup (years), mean (SD) | 8.6 (2.1) | 8.6 (2.0) | 8.6 (2.0) | 8.6 (2.1) | 8.6 (2.1) | 8.6 (2.1) | 8.6 (2.0) | 8.7 (2.0) | 8.6 (2.1) | 8.7 (2.0) | 8.6 (2.0) | 8.4 (2.2) | 8.6 (2.1) |