TY - JOUR AU - Zhao, Xing AU - Papadopoulos, Anestis AU - Ibusuki, Shinichi AU - Bichara, David A. AU - Saris, Daniel B. AU - Malda, Jos AU - Anseth, Kristi S. AU - Gill, Thomas J. AU - Randolph, Mark A. PY - 2016 DA - 2016/06/03 TI - Articular cartilage generation applying PEG-LA-DM/PEGDM copolymer hydrogels JO - BMC Musculoskeletal Disorders SP - 245 VL - 17 IS - 1 AB - Injuries to the human native cartilage tissue are particularly problematic because cartilage has little to no ability to heal or regenerate itself. Employing a tissue engineering strategy that combines suitable cell sources and biomimetic hydrogels could be a promising alternative to achieve cartilage regeneration. However, the weak mechanical properties may be the major drawback to use fully degradable hydrogels. Besides, most of the fully degradable hydrogels degrade too fast to permit enough extracellular matrix (ECM) production for neocartilage formation. In this study, we demonstrated the feasibility of neocartilage regeneration using swine articular chondrocytes photoencapsualted into poly (ethylene glycol) dimethacrylate (PEGDM) copolymer hydrogels composed of different degradation profiles: degradable (PEG-LA-DM) and nondegradable (PEGDM) macromers in molar ratios of 50/50, 60/40, 70/30, 80/20, and 90/10. SN - 1471-2474 UR - https://doi.org/10.1186/s12891-016-1100-1 DO - 10.1186/s12891-016-1100-1 ID - Zhao2016 ER -