Fig. 4

Cytokine response in wild-type and Padi4^−/− mice after collagen-induced arthritis (CIA) treatment. Wild-type (n = 30) and Padi4^−/− (n = 24) mice were challenged with CIA, and serum cytokine protein levels were determined by ELISA on day 28. a tumor necrosis factor alpha (TNF-α), b interleukin (IL)-1β, c Granulocyte-macrophage colony-stimulating factor (GM-CSF), d IL-6. * P < 0.01, **P < 0.001 (Student’s t-test)