Effect | Estimated odds ratio | 95Â % CI | p value |
---|---|---|---|
Pre-index GI event (ref: no pre-index GI event) | 0.846 | (0.74, 0.95) | 0.0009 |
Post-index GI event (ref: no post-index GI event) | 0.654 | (0.57, 0.74) | <0.0001 |
Age group | Â | Â | Â |
 65–74 vs. 55–64 | 0.962 | (0.87, 1.06) | 0.0613 |
 75–84 vs. 55–64 | 0.785 | (0.71, 0.87) | 0.0023 |
 85+ vs. 55–64 | 0.720 | (0.54, 0.97) | 0.0624 |
Pre-index Medication Use | Â | Â | Â |
 Gastro-protective agents | 0.684 | (0.62, 0.76) | <0.0001 |
 NSAIDs | 1.066 | (0.97, 1.17) | 0.1835 |
 Glucocorticoids | 0.982 | (0.88, 1.09) | 0.7334 |
Charlson comorbidity index score | 0.961 | (0.92, 1.01) | 0.0963 |