Effect | Initiated bisphosphonates vs. initiated non-bisphosphonates | ||
---|---|---|---|
Post-index GI event (ref: no post-index GI event) | Odds ratio | 95Â % CI | p value |
 Among patients without pre-index GI problems | 0.591 | (0.55, 0.64) | <0.0001 |
 Among patients with pre-index GI problems | 0.631 | (0.58, 0.68) | <0.0001 |
Age group | Â | Â | Â |
 65–74 vs. 55–64 | 1.393 | (1.00, 1.95) | 0.0603 |
 75–84 vs. 55–64 | 1.576 | (1.18, 2.01) | <0.0001 |
 85+ vs. 55–64 | 1.154 | (0.77, 1.75) | 0.2332 |
Pre-index medication use | Â | Â | Â |
 Gastro-protective agents | 1.693 | (1.21, 2.38) | <0.0001 |
 NSAIDs | 1.094 | (0.86, 1.39) | 0.3443 |
 Glucocorticoids | 1.066 | (0.78, 1.46) | 0.4532 |
Charlson comorbidity index score | 1.004 | (0.88, 1.15) | 0.3594 |