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Table 1 Patient baseline characteristics

From: Association between gastrointestinal events and osteoporosis treatment initiation in women diagnosed with osteoporosis in France: a retrospective analysis

   Post-index GI status n = 10,292   Treatment initiated (treated patients only) n = 2603  
Baseline characteristic All patients (n = 10,292) With post-index GI events (n = 1180) Without post-index GI events (n = 9112) p value Initiated BIS treatment (n = 2422) Initiated non-BIS treatment (n = 181) p value
Age, mean (SD) 70.3 (8.2) 71.4 (7.5) 70.2 (8.3) 0.010 71.5 (9.4) 70.7 (9.2) 0.074
Charlson comorbidity index score, mean (SD) 0.92 (1.22) 1.12 (1.04) 0.89 (0.76) <.001 1.26 (1.35) 0.71 (1.04) <.001
Common OP-related comorbidities, n (%)        
 Chronic inflammatory bowel disease 59 (0.6) 7 (0.6) 52 (0.6) 0.995 17 (0.7) 1 (0.6) 0.972
 Chronic inflammatory joint disease 623 (6.1) 95 (8.1) 528 (5.8) <.001 109 (4.5) 3 (1.7) 0.211
 Celiac disease 2 (0.0) 0 (0.0) 2 (0.0) 0.856 0 (0.0) 0 (0.0) NA
 Diabetes (type 1 or 2) 1649 (16.0) 246 (20.8) 1403 (15.4) 0.003 191 (4.5) 14 (7.7) 0.760
 Depression 2456 (23.9) 497 (42.1) 1959 (21.5) <.001 254 (10.5) 19 (10.5) 0.924
 Chronic kidney disease 120 (1.2) 20 (1.7)) 100 (1.1) 0.045 3 (0.1) 1 (0.6) 0.215
 Fatigue 434 (4.2) 88 (7.5) 346 (3.8) <.001 36 (1.5) 2 (1.1) 0.398
 Hypertension 8113 (78.8) 1042 (88.3) 7071 (77.6) <.001 1223 (50.5) 73 (40.3) 0.002
 GI mucositis & urination problems 543 (5.3) 106 (9.0) 437 (4.8) <.001 95 (3.9) 6 (3.3) 0.075
 Hyperparathyroidism 36 (0.3) 4 (0.3) 32 (0.4) 0.879 11 (0.5) 1 (0.6) 0.510
 Vitamin D deficiency 3 (0.0) 0 (0.0) 3 (0.0) 0.785 0 (0.0) 0 (0.0) NA
OP-related fractures, n (%) 778 (7.6) 138 (11.7) 640 (7.0) 0.344 304 (12.6) 38 (21.0) 0.231
GI-related drug use, n (%)        
 Glucocorticoids 4382 (42.6) 728 (61.7) 3654 (40.1) <.001 509 (21.0) 32 (17.7) 0.180
 NSAIDs 7633 (74.2) 1036 (87.8) 6597 (72.4) <.001 1017 (42.0) 72 (39.8) 0.155
 Gastro-protective agents 3987 (38.7) 552 (46.8) 3435 (37.7) <.001 654 (27.0) 36 (19.9) 0.004
GI events (pre-index), n (%) 1452 (14.1) 414 (35.1) 1038 (11.4) <.001 304 (12.6) 38 (21.0) 0.231
  1. GI gastrointestinal, NA not applicable, NSAIDs non-steroidal anti-inflammatory drugs