Table 1 Patient baseline characteristics
|  |  | Post-index GI status n = 10,292 |  | Treatment initiated (treated patients only) n = 2603 |  | ||
|---|---|---|---|---|---|---|---|
Baseline characteristic | All patients (n = 10,292) | With post-index GI events (n = 1180) | Without post-index GI events (n = 9112) | p value | Initiated BIS treatment (n = 2422) | Initiated non-BIS treatment (n = 181) | p value |
Age, mean (SD) | 70.3 (8.2) | 71.4 (7.5) | 70.2 (8.3) | 0.010 | 71.5 (9.4) | 70.7 (9.2) | 0.074 |
Charlson comorbidity index score, mean (SD) | 0.92 (1.22) | 1.12 (1.04) | 0.89 (0.76) | <.001 | 1.26 (1.35) | 0.71 (1.04) | <.001 |
Common OP-related comorbidities, n (%) | Â | Â | Â | Â | Â | Â | Â |
 Chronic inflammatory bowel disease | 59 (0.6) | 7 (0.6) | 52 (0.6) | 0.995 | 17 (0.7) | 1 (0.6) | 0.972 |
 Chronic inflammatory joint disease | 623 (6.1) | 95 (8.1) | 528 (5.8) | <.001 | 109 (4.5) | 3 (1.7) | 0.211 |
 Celiac disease | 2 (0.0) | 0 (0.0) | 2 (0.0) | 0.856 | 0 (0.0) | 0 (0.0) | NA |
 Diabetes (type 1 or 2) | 1649 (16.0) | 246 (20.8) | 1403 (15.4) | 0.003 | 191 (4.5) | 14 (7.7) | 0.760 |
 Depression | 2456 (23.9) | 497 (42.1) | 1959 (21.5) | <.001 | 254 (10.5) | 19 (10.5) | 0.924 |
 Chronic kidney disease | 120 (1.2) | 20 (1.7)) | 100 (1.1) | 0.045 | 3 (0.1) | 1 (0.6) | 0.215 |
 Fatigue | 434 (4.2) | 88 (7.5) | 346 (3.8) | <.001 | 36 (1.5) | 2 (1.1) | 0.398 |
 Hypertension | 8113 (78.8) | 1042 (88.3) | 7071 (77.6) | <.001 | 1223 (50.5) | 73 (40.3) | 0.002 |
 GI mucositis & urination problems | 543 (5.3) | 106 (9.0) | 437 (4.8) | <.001 | 95 (3.9) | 6 (3.3) | 0.075 |
 Hyperparathyroidism | 36 (0.3) | 4 (0.3) | 32 (0.4) | 0.879 | 11 (0.5) | 1 (0.6) | 0.510 |
 Vitamin D deficiency | 3 (0.0) | 0 (0.0) | 3 (0.0) | 0.785 | 0 (0.0) | 0 (0.0) | NA |
OP-related fractures, n (%) | 778 (7.6) | 138 (11.7) | 640 (7.0) | 0.344 | 304 (12.6) | 38 (21.0) | 0.231 |
GI-related drug use, n (%) | Â | Â | Â | Â | Â | Â | Â |
 Glucocorticoids | 4382 (42.6) | 728 (61.7) | 3654 (40.1) | <.001 | 509 (21.0) | 32 (17.7) | 0.180 |
 NSAIDs | 7633 (74.2) | 1036 (87.8) | 6597 (72.4) | <.001 | 1017 (42.0) | 72 (39.8) | 0.155 |
 Gastro-protective agents | 3987 (38.7) | 552 (46.8) | 3435 (37.7) | <.001 | 654 (27.0) | 36 (19.9) | 0.004 |
GI events (pre-index), n (%) | 1452 (14.1) | 414 (35.1) | 1038 (11.4) | <.001 | 304 (12.6) | 38 (21.0) | 0.231 |