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Table 1 Study characteristics and key results

From: Clopidogrel and hip fractures, is it safe? A systematic review and meta-analysis

Report Type of study Study size Clopidogrel group- (n) Control/Non-clopidogrel group- (n) Key results
Harty et al. 2007 [68] Case-control (Retrospective) 180 21 159 Higher mortality rate in CG than NCG (p = 0.003)
CG were delayed to surgery compared to NCG (7.2 vs 2.1 days, p = 0.03)
Johansen et al. 2008 [56] Case-control (Retrospective) 17 (<5 days) 7
(>5 days) 10
  Less drop in Hb in the CG > 5 group (p = 0.01)
Thromboembolic complications in delayed group (1 death from pulmonary embolus)
Sim and Gonski 2009 [57] Case-control (Retrospective) 135 21
(<5 days) 16
(>5 days) 5
114 No significant difference in all outcomes for:
CG vs NCG
CG < 5 vs CG > 5
Cox et al 2009 [58] Case-control
(Retrospective)
20 (<7 days) 11
(>7 days) 9
  Less drop in Hb in the CG >7 group (p < 0.05)
Nydick et al. 2010 [53] Case-control (Retrospective) 50 (23 27 No significant difference in outcomes between CG and NCG
Chechik et al. 2011 [52] Case-control (Prospective) 51 29 22 Significantly more blood loss in patients on Clopidogrel
Wallace et al. 2012 [63] Case-control (Retrospective) 110 52 58 Statistically significant higher transfusion rates in CG (56 % CG vs 31 % NCG, p = 0.01)
Collinge et al. 2012 [62] Case-control (Retrospective) 659 40 619 No significant difference in outcomes between CG and NCG
Chechik et al. 2012 [59] Case-control (Retrospective) 60 (<5 days) 30
(>5 days) 30
  No significant difference in outcomes between
CG < 5 and CG >5
Hossain et al. 2013 [61] Case-control (Retrospective) 102 50 52 No significant difference in outcomes between CG and NCG
Feely et al. 2013 [54] Case-control (Retrospective) 120 40 80 No significant difference in outcomes between CG and NCG
Al Khudairy et al. 2013 [60] Case-control (Retrospective) 47 (<5 days) 24
(>5 days) 23
  No significant difference in outcomes between
CG < 5 and CG >5
CG > 5 had 2 pre-op cardiac complications and 4 patients died from cardiac complications.
CG < 5 had 2 patients die from cardiac complications.
Wordsworth et al. 2013 [55] Case-control (Prospective) 1225 30 1195 No significant difference in outcomes between CG and NCG
Manaqibwala et al. 2014 [64] Case-control (Retrospective) 162 15 147 No significant difference in time to outcomes between CG and NCG
Significantly lower preop Hb and higher ASA in CG