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Fig. 2 | BMC Musculoskeletal Disorders

Fig. 2

From: Intra-articular injection of mono-iodoacetate induces osteoarthritis of the hip in rats

Fig. 2

Time course of X-ray and histopathology of the hip in MIA group. After 7 days (ad), 14 days (eh), 28 days (il), 42 days (mp), and 56 days (qt). Anteroposterior (a, e, i, m, and q) and lateral (b, f, j, n, and r) radiographs of the rat hip. Hematoxylin and eosin (c, g, k, o, and s) and Safranin O (d, h, l, p, t) staining. Scale bars are 1 mm. This shows no evidence of narrowing of the joint space (a, b) or degeneration (c, d) at 7 days, but possible joint space narrowing (e, f) and extensive involvement of cartilage (g, h) at 14 days, definite joint space narrowing and deformity of the femoral head (i, j) and multifocal collapse of bony trabeculae in the acetabulum and the femoral head (k, l) at 28 days, severely deformed femoral head and erosive acetabulum (m, n) and peeling of articular cartilage and exposure of subchondral bone (o, p) at 42 days, and destruction of the femoral head and acetabulum (q, r) and complete disappearance of articular cartilage (s, t) at 56 days

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