From: Opioid use after total hip arthroplasty surgery is associated with revision surgery
1 Year Revision | 5 Years Revision | ||||||
---|---|---|---|---|---|---|---|
OMEs (mg range), Reference=No opioid | Crude HR | Adjusted HR | P Value | Crude HR | Adjusted HR | P Value | |
Days 1 - 90a | Low (<150) | 1.22 (0.70-2.12) | 1.12 (0.64-1.96) | 0.696 | 1.39 (0.96-2.00) | 1.29 (0.89-1.86) | 0.177 |
Medium-low (150–349.9) | 1.16 (0.75-1.80) | 1.01 (0.65-1.56) | 0.973 | 1.16 (0.86-1.58) | 1.06 (0.78-1.44) | 0.715 | |
Medium-high (350–839.9) | 1.62 (1.07-2.47) | 1.32 (0.86-2.04) | 0.209 | 1.34 (0.97-1.85) | 1.14 (0.82-1.59) | 0.422 | |
High (≥840) | 1.56 (1.01-2.40) | 1.02 (0.60-1.76) | 0.943 | 1.69 (1.26-2.27) | 1.24 (0.85-1.81) | 0.269 | |
Days 91 - 180a | Low (<116.5) | 0.91 (0.28-2.90) | 0.77 (0.24-2.49) | 0.667 | 1.48 (0.92-2.40) | 1.35 (0.83-2.18) | 0.230 |
Medium-low (116.5-399.9) | 1.98 (0.90-4.34) | 1.64 (0.74-3.66) | 0.223 | 1.15 (0.68-1.94) | 0.99 (0.58-1.69) | 0.982 | |
Medium-high (400–1119.9) | 2.80 (1.43-5.49) | 2.22 (1.08-4.56) | 0.030 | 1.98 (1.32-2.97) | 1.66 (1.08-2.56) | 0.022 | |
High (≥1120) | 3.14 (1.60-6.15) | 2.64 (1.03-6.74) | 0.042 | 2.15 (1.41-3.27) | 2.11 (1.13-3.96) | 0.020 | |
Days 181 - 270b | Low (<116.5) | 2.05 (0.73-5.77) | 1.70 (0.60-4.84) | 0.321 | 1.34 (0.80-2.27) | 1.21 (0.72-2.06) | 0.472 |
Medium-low (116.5-399.9) | 3.11 (1.31-7.41) | 2.42 (1.00-5.87) | 0.050 | 1.48 (0.89-2.46) | 1.25 (0.75-2.10) | 0.396 | |
Medium-high (400–1199.9) | 2.05 (0.73-5.78) | 1.28 (0.43-3.85) | 0.659 | 1.44 (0.87-2.39) | 1.01 (0.59-1.73) | 0.977 | |
High (≥1200) | 2.16 (0.77-6.10) | 0.48 (0.08-3.01) | 0.432 | 1.60 (0.96-2.67) | 0.65 (0.27-1.60) | 0.349 | |
Days 271 - 360c | Low (<95) | 1.22 (0.16-9.31) | NA | NA | 1.35 (0.77-2.36) | 1.19 (0.67-2.10) | 0.238 |
Medium-low (95–399.9) | 2.47 (0.56-10.88) | NA | NA | 1.79 (1.09-2.95) | 1.55 (0.94-2.58) | 0.088 | |
Medium-high (400–1216.7) | 4.96 (1.63-15.07) | NA | NA | 1.81 (1.10-2.97) | 1.41 (0.83-2.38) | 0.203 | |
High (≥1216.8) | 4.01 (1.15-13.96) | NA | NA | 1.93 (1.16-3.23) | 1.22 (0.55-2.73) | 0.627 |