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Table 3 Crude and Adjusted Risk of 1 Year and 5 Year Revisions by Total Amount of Oral Morphine Equivalent (mg) Quartiles by 90 day Periods Post- Total Hip Arthroplasty

From: Opioid use after total hip arthroplasty surgery is associated with revision surgery

   1 Year Revision 5 Years Revision
  OMEs (mg range), Reference=No opioid Crude HR Adjusted HR P Value Crude HR Adjusted HR P Value
Days 1 - 90a Low (<150) 1.22 (0.70-2.12) 1.12 (0.64-1.96) 0.696 1.39 (0.96-2.00) 1.29 (0.89-1.86) 0.177
  Medium-low (150–349.9) 1.16 (0.75-1.80) 1.01 (0.65-1.56) 0.973 1.16 (0.86-1.58) 1.06 (0.78-1.44) 0.715
  Medium-high (350–839.9) 1.62 (1.07-2.47) 1.32 (0.86-2.04) 0.209 1.34 (0.97-1.85) 1.14 (0.82-1.59) 0.422
  High (≥840) 1.56 (1.01-2.40) 1.02 (0.60-1.76) 0.943 1.69 (1.26-2.27) 1.24 (0.85-1.81) 0.269
Days 91 - 180a Low (<116.5) 0.91 (0.28-2.90) 0.77 (0.24-2.49) 0.667 1.48 (0.92-2.40) 1.35 (0.83-2.18) 0.230
Medium-low (116.5-399.9) 1.98 (0.90-4.34) 1.64 (0.74-3.66) 0.223 1.15 (0.68-1.94) 0.99 (0.58-1.69) 0.982
Medium-high (400–1119.9) 2.80 (1.43-5.49) 2.22 (1.08-4.56) 0.030 1.98 (1.32-2.97) 1.66 (1.08-2.56) 0.022
High (≥1120) 3.14 (1.60-6.15) 2.64 (1.03-6.74) 0.042 2.15 (1.41-3.27) 2.11 (1.13-3.96) 0.020
Days 181 - 270b Low (<116.5) 2.05 (0.73-5.77) 1.70 (0.60-4.84) 0.321 1.34 (0.80-2.27) 1.21 (0.72-2.06) 0.472
Medium-low (116.5-399.9) 3.11 (1.31-7.41) 2.42 (1.00-5.87) 0.050 1.48 (0.89-2.46) 1.25 (0.75-2.10) 0.396
Medium-high (400–1199.9) 2.05 (0.73-5.78) 1.28 (0.43-3.85) 0.659 1.44 (0.87-2.39) 1.01 (0.59-1.73) 0.977
High (≥1200) 2.16 (0.77-6.10) 0.48 (0.08-3.01) 0.432 1.60 (0.96-2.67) 0.65 (0.27-1.60) 0.349
Days 271 - 360c Low (<95) 1.22 (0.16-9.31) NA NA 1.35 (0.77-2.36) 1.19 (0.67-2.10) 0.238
Medium-low (95–399.9) 2.47 (0.56-10.88) NA NA 1.79 (1.09-2.95) 1.55 (0.94-2.58) 0.088
Medium-high (400–1216.7) 4.96 (1.63-15.07) NA NA 1.81 (1.10-2.97) 1.41 (0.83-2.38) 0.203
  High (≥1216.8) 4.01 (1.15-13.96) NA NA 1.93 (1.16-3.23) 1.22 (0.55-2.73) 0.627
  1. OME=oral morphine equivalents. NA= Not applicable
  2. aModels adjusted for age, gender, primary diagnosis, RxRisk-V number of co-morbidities, back pain, prior opioid use, and NSAID use
  3. b1 year revision model adjusted for prior opioid use, back pain and RxRisk. 5 year revision model adjusted for age, gender, primary diagnosis, RxRisk-V number of co-morbidities, back pain, prior opioid use, and NSAID use
  4. c1 year revision estimates could not be adjusted because of the small number of events in this period (N=24). 5 year revision model adjusted for age, gender, primary diagnosis, RxRisk-V number of co-morbidities, back pain, prior opioid use, and NSAID use