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Table 3 Crude and Adjusted Risk of 1 Year and 5 Year Revisions by Total Amount of Oral Morphine Equivalent (mg) Quartiles by 90 day Periods Post- Total Hip Arthroplasty

From: Opioid use after total hip arthroplasty surgery is associated with revision surgery

  

1 Year Revision

5 Years Revision

 

OMEs (mg range), Reference=No opioid

Crude HR

Adjusted HR

P Value

Crude HR

Adjusted HR

P Value

Days 1 - 90a

Low (<150)

1.22 (0.70-2.12)

1.12 (0.64-1.96)

0.696

1.39 (0.96-2.00)

1.29 (0.89-1.86)

0.177

 

Medium-low (150–349.9)

1.16 (0.75-1.80)

1.01 (0.65-1.56)

0.973

1.16 (0.86-1.58)

1.06 (0.78-1.44)

0.715

 

Medium-high (350–839.9)

1.62 (1.07-2.47)

1.32 (0.86-2.04)

0.209

1.34 (0.97-1.85)

1.14 (0.82-1.59)

0.422

 

High (≥840)

1.56 (1.01-2.40)

1.02 (0.60-1.76)

0.943

1.69 (1.26-2.27)

1.24 (0.85-1.81)

0.269

Days 91 - 180a

Low (<116.5)

0.91 (0.28-2.90)

0.77 (0.24-2.49)

0.667

1.48 (0.92-2.40)

1.35 (0.83-2.18)

0.230

Medium-low (116.5-399.9)

1.98 (0.90-4.34)

1.64 (0.74-3.66)

0.223

1.15 (0.68-1.94)

0.99 (0.58-1.69)

0.982

Medium-high (400–1119.9)

2.80 (1.43-5.49)

2.22 (1.08-4.56)

0.030

1.98 (1.32-2.97)

1.66 (1.08-2.56)

0.022

High (≥1120)

3.14 (1.60-6.15)

2.64 (1.03-6.74)

0.042

2.15 (1.41-3.27)

2.11 (1.13-3.96)

0.020

Days 181 - 270b

Low (<116.5)

2.05 (0.73-5.77)

1.70 (0.60-4.84)

0.321

1.34 (0.80-2.27)

1.21 (0.72-2.06)

0.472

Medium-low (116.5-399.9)

3.11 (1.31-7.41)

2.42 (1.00-5.87)

0.050

1.48 (0.89-2.46)

1.25 (0.75-2.10)

0.396

Medium-high (400–1199.9)

2.05 (0.73-5.78)

1.28 (0.43-3.85)

0.659

1.44 (0.87-2.39)

1.01 (0.59-1.73)

0.977

High (≥1200)

2.16 (0.77-6.10)

0.48 (0.08-3.01)

0.432

1.60 (0.96-2.67)

0.65 (0.27-1.60)

0.349

Days 271 - 360c

Low (<95)

1.22 (0.16-9.31)

NA

NA

1.35 (0.77-2.36)

1.19 (0.67-2.10)

0.238

Medium-low (95–399.9)

2.47 (0.56-10.88)

NA

NA

1.79 (1.09-2.95)

1.55 (0.94-2.58)

0.088

Medium-high (400–1216.7)

4.96 (1.63-15.07)

NA

NA

1.81 (1.10-2.97)

1.41 (0.83-2.38)

0.203

 

High (≥1216.8)

4.01 (1.15-13.96)

NA

NA

1.93 (1.16-3.23)

1.22 (0.55-2.73)

0.627

  1. OME=oral morphine equivalents. NA= Not applicable
  2. aModels adjusted for age, gender, primary diagnosis, RxRisk-V number of co-morbidities, back pain, prior opioid use, and NSAID use
  3. b1 year revision model adjusted for prior opioid use, back pain and RxRisk. 5 year revision model adjusted for age, gender, primary diagnosis, RxRisk-V number of co-morbidities, back pain, prior opioid use, and NSAID use
  4. c1 year revision estimates could not be adjusted because of the small number of events in this period (N=24). 5 year revision model adjusted for age, gender, primary diagnosis, RxRisk-V number of co-morbidities, back pain, prior opioid use, and NSAID use