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Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Clinical trial and in-vitro study comparing the efficacy of treating bony lesions with allografts versus synthetic or highly-processed xenogeneic bone grafts

Fig. 5

a Osteocalcin (OC) was detected in all probes. Although we noted a tendency toward slightly better results in the BioOss®-group and after 1 week’s cultivation; differences were statistically significant only in the ACB group (allogeneic cancellous bone), decreasing from 1 to 3 weeks (p = 0.002). b The same pattern is observed for osteopontin (OPN), which was detectable in all samples but revealed a tendency toward slightly better results in the BioOss®-group and after 1 week of cultivation; differences were statistically significant in the ACB (allogeneic cancellous bone) group only, decreasing from 1 to 3 weeks (p = 0.0045). c Osteoprotegerin (OPG) was also secreted by human osteoblasts seeded onto BioOss® or allograft (ACB). Here again the tendency toward slightly better results in the first 1 week: OPG concentrations in the supernatant of cultivated grafts were higher in the BioOss® group after 3 weeks (p = 0.039). d Leptin was detected in all probes. Comparing the different biomaterials and time points: differences attained statistical significance in the ACB group only (allogeneic cancellous bone), decreasing from 1 to 3 weeks (p = 0.002). e Adiponectin was detected in all probes. Comparing the different biomaterials and time points: differences attained statistical significance in the ACB group only (allogeneic cancellous bone), decreasing from 1 to 3 weeks (p = 0.04)

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