Fig. 5From: Macrophage migration inhibitory factor enhances lipopolysaccharide-induced fibroblast proliferation by inducing toll-like receptor 4Co-stimulatory effect of MIF on LPS-induced fibroblast proliferation. LPS was used at 25 μg / ml, alongside several MIF concentrations, including 375 ng/ml, 187 ng/ml and 93 ng/ml. In presence of LPS, OD450 value increased with MIF dose, which indicated MIF could co-stimulate fibroblast proliferation. Without LPS, MIF could not stimulate fibroblast proliferation within the dose range tested. This indicated that stimulatory effect of MIF on fibroblast proliferation was indirect, requiring LPSBack to article page