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Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Macrophage migration inhibitory factor enhances lipopolysaccharide-induced fibroblast proliferation by inducing toll-like receptor 4

Fig. 5

Co-stimulatory effect of MIF on LPS-induced fibroblast proliferation. LPS was used at 25 μg / ml, alongside several MIF concentrations, including 375 ng/ml, 187 ng/ml and 93 ng/ml. In presence of LPS, OD450 value increased with MIF dose, which indicated MIF could co-stimulate fibroblast proliferation. Without LPS, MIF could not stimulate fibroblast proliferation within the dose range tested. This indicated that stimulatory effect of MIF on fibroblast proliferation was indirect, requiring LPS

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