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Table 1 Demographic, biochemical and immunological data for the 12 patients with pSS

From: Tubulointerstitial nephritis in primary Sjögren syndrome: clinical manifestations and response to treatment

Patient Age Sex Presentation/reason for referral Extra-renal clinical features ANA Anti-Ro Anti-La RF (0–20 IU/ml) C3 (70–165 mg/dL) C4 (16–54 mg/dL) IgG (7-16 g/L) Serum protein electrophoresis ESR (mm/hr) Creatinine (μmol/L) Urine PCR (mg/mmol)
1 54 Female Renal impairment Urinary Symptoms Sicca, Non-specific (generally unwell, fatigue, poor energy) positive (>1/1000 fine speckled) Positive Negative 145 128 15 24.9 Polyclonal increase in immunoglobulins 107 168 0
2 52 Female Hypokalaemic acidosis with paralysis Sicca, Non-specific (generally unwell, fatigue, poor energy), arthralgias positive (>1/1000 fine speckled) Positive Positive N/A 137 29 27.5 Polyclonal increase in immunoglobulins 88 97 27
3 36 Female Hypokalaemic acidosis Sicca, Non-specific (generally unwell, fatigue, poor energy), arthralgias, parotitis, low mood. positive (>1/1000 fine speckled) Positive Positive 718 148 21 24.8 Polyclonal increase in immunoglobulins 35 88 102
4 45 Female Renal impairment Sicca positive (>1/1000 fine speckled) Positive Positive 743 139 15 37.6 Polyclonal increase in immunoglobulins 121 124 N/A
5 71 Female Hypokalaemic acidosis with paralysis Sicca, Non-specific (generally unwell, fatigue, poor energy), arthralgias positive (>1/1000 fine speckled) Positive Negative 618 124 21 21.3 Polyclonal increase in immunoglobulins 86 106 101
6 54 Female Renal impairment Stones Sicca, Non-specific (generally unwell, fatigue, poor energy) positive (>1/1000 fine speckled) Positive Positive 69 89 16 18.5 N/A 5 186 50
7 48 Female Renal impairment Nephrocalcinosis Sicca, Non-specific (generally unwell, fatigue, poor energy), rash positive (>1/1000 fine speckled) Positive Positive 93 N/A N/A 14 Polyclonal increase in immunoglobulins 33 133 127
8 43 Female Renal impairment Nephrocalcinosis Sicca, Non-specific (generally unwell, fatigue, poor energy) positive (>1/1000 fine speckled) Positive Positive <20 108 21 19.7 Polyclonal increase in immunoglobulins N/A 141 46
9 51 Female Renal impairment Sicca, Non-specific (generally unwell, fatigue, poor energy) positive (>1/1000 fine speckled) Positive Negative <20 70 16 19.9 N/A 5 168 0
10 61 Female Renal impairment Sicca, non-specific (generally unwell, fatigue, poor energy) positive (>1/1000 fine speckled) Positive Positive 158 85 20 13.7 Polyclonal increase in immunoglobulins 25 115 0
11 72 Female Renal impairment Sicca, non-specific (generally unwell, fatigue, poor energy), arthralgia and GI upset. positive (>1/1000 fine speckled) Positive Negative N/A 88 14 17.6 Paraprotein with immunoparesis N/A 133 N/A
12 53 Male Renal impairment Sicca, neuropathy, vasculitic rash, cryoglobulinaemia positive (>1/1000 fine speckled) Positive Negative 1370 96 3 12.4 Type 1 IgM kappa cryoglobulin 65 133 40